Transforming growth factor β signaling in uterine development and function  

作　　者：Qinglei Li 

机构地区：[1]Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University,College Station

出　　处：《Journal of Animal Science and Biotechnology》2015年第2期142-150,共9页畜牧与生物技术杂志（英文版）

基　　金：supported by the National Institutes of Health grant R21HD073756 from the Eunice Kennedy Shriver National Institute of Child Health & Human Development and the Ralph E. Powe Junior Faculty Enhancement Awards from Oak Ridge Associated Universities

摘　　要：Transforming growth factor β （TGFβ） superfamily is evolutionarily conserved and plays fundamental roles in cell growth and differentiation. Mounting evidence supports its important role in female reproduction and development. TGFBs1-3 are founding members of this growth factor family, however, the in vivo function of TGFβ signaling in the uterus remains poorly defined. By drawing on mouse and human studies as a main source, this review focuses on the recent progress on understanding TGFβ signaling in the uterus. The review also considers the involvement of dysregulated TGFβ signaling in pathological conditions that cause pregnancy loss and fertility problems in women.Transforming growth factor β （TGFβ） superfamily is evolutionarily conserved and plays fundamental roles in cell growth and differentiation. Mounting evidence supports its important role in female reproduction and development. TGFBs1-3 are founding members of this growth factor family, however, the in vivo function of TGFβ signaling in the uterus remains poorly defined. By drawing on mouse and human studies as a main source, this review focuses on the recent progress on understanding TGFβ signaling in the uterus. The review also considers the involvement of dysregulated TGFβ signaling in pathological conditions that cause pregnancy loss and fertility problems in women.

关 键 词：DECIDUALIZATION DEVELOPMENT Embryonic development Implantation MYOMETRIUM Pregnancy Transforminq clrowth factor β. Uterus 

分 类 号：S857.2[农业科学—临床兽医学]