宫颈上皮内病变环形电切术后人乳头瘤病毒分型检测在随诊中的临床意义  

Clinical Significance of the HPV Detection and Typing in the Follow-up After the LEEP of CIN

作　　者：金芬 阎冰冰 徐秀华 邵小光 

机构地区：[1]大连市妇女儿童医疗中心,辽宁大连116038

出　　处：《中国医药指南》2015年第13期34-35,共2页Guide of China Medicine

摘　　要：目的探讨子宫颈上皮内瘤变(CIN)环形电切术(LEEP)后CIN复发与再次感染人乳头瘤病毒(HPV)之间的关系。方法选择2009年4月至2011年10月在大连市妇幼保健院因子宫颈高级别病变接受LEEP治疗,并在术前术后接受HPV分型检测的259例为研究对象,进行阴道镜检查及定位活检,以病理学结果作为诊断CIN的金标准。结果入组259例HPV检出率为98.1%(254/259),LEEP后随诊中检出HPV 48例。CIN复发者以HPV单一亚型感染为主。结论 CIN患者LEEP后再次检出与术前相同HPV亚型是CIN复发的高危因素,故随诊中检查宫颈脱落细胞学的同时定期进行HPV分型检测具有重要的临床指导意义。Objective To explore the the relationship between the cervical intraepithelial neoplasia（CIN）loop electrosurgical excision procedure（LEEP）after CIN relapse and re infection of human papillomavirus（HPV）. Method 259 cases of patients with factor of high grade cervical lesions and were treated by LEEP, and before and after operation were accepted the HPV genotyping, and were given colposcopy and biopsy under colposcopy. The pathology results were regarded as the gold standard for the diagnosis of CIN. Results The detection rate of HPV of the group of 259 cases was 98.1%（254/259）, and there were 48 cases of HPV positive were detected after follow-up of LEEP, the recurrence rate of CIN of Single subtype HPV infection after operation was significantly higher than that of the HPV mixed infections. Conclusion Single infection with the same HPV subtypes between pre- and post-LEEP surgery in CIN patients is a high risk factor for CIN recurrence. Therefore cervical cytology in combination with periodic HPV subtype testing can be of great clinical significance.

关 键 词：LEEP CIN复发 HPV亚型 单一亚型感染 

分 类 号：R737.33[医药卫生—肿瘤]