再血管化和牙组织工程化牙髓再生的研究进展  

Research progress on dental pulp tissue regeneration based on revascularization and tooth tissue engineering

作　　者：贺露[1] 郭俊[1] 杨健[1] 

机构地区：[1]南昌大学附属口腔医院牙体牙髓病科,南昌330006

出　　处：《国际口腔医学杂志》2015年第4期485-491,共7页International Journal of Stomatology

基　　金：江西省自然科学基金(20114BAB205094)

摘　　要：牙髓再生一是通过刺激根尖部出血,诱导根尖部宿主细胞迁移和分化,共同实现牙髓的再血管化,使牙髓腔中再生长出活性组织实现牙根的继续发育,即再血管化治疗;再是利用工程学原理将干细胞辅以支架移植到根管,诱导分化新生牙髓,实现牙本质牙髓再生。本文就再血管化及其牙髓再生,牙组织工程及其牙髓再生研究进展以及存在的问题等作一综述。Pulpitis and periapieal periodontitis are mainly treated with root canal therapy, and immature permanent tooth is treated through apexifieation. These treatment modalities exhibit some limitations that can be theoretically surmounted through dental pulp regeneration, thus, dental pulp tissue regeneration could be a superior treatment of pulpitis and periapical periodontitis. This technique can be performed using two approaches. The first approach is based on host cells from the apical region; these cells are induced to migrate toward the interior of the root canal and differentiate into a vascularized pulp tissue. The other approach is based on the transplantation of stem cells into the root canal and the differentiation of such cells into a new dental pulp. This paper summarized the research progress and challenges on dental pulp regeneration based on revascularization and tooth tissue engineering.

关 键 词：牙髓再生 再血管化 干细胞 牙组织工程 

分 类 号：R781.31[医药卫生—口腔医学]