介入联合含洛铂方案治疗原发性肝癌的效果观察  

THE EFFECT OF LOBAPLATIN COMBINED WITH FLOXURIDINE/PIRARUBICIN ON PRIMARY LIVER CANCER

作　　者：王旭杰[1] 冯卫华[2] 于春鹏[1] 王松[1] 

机构地区：[1]青岛大学附属医院介入医学科,山东青岛2661001 [2]青岛大学附属医院放射科,山东青岛2661001

出　　处：《齐鲁医学杂志》2015年第3期280-283,共4页Medical Journal of Qilu

摘　　要：目的探讨含洛铂方案联合经动脉化疗栓塞术（TACE）治疗不可切除原发性肝癌的临床效果及安全性。方法对34例不能手术切除的肝细胞癌病人采用洛铂联合氟尿苷、吡柔比星方案行TACE术，观察术后不良反应。术后4～6周复查血常规、肝功能、甲胎蛋白（AFP）及影像学检查，进行疗效评估，根据结果行下个周期治疗。并进行定期随访。结果本组34例病人完全缓解1例（2．9％），部分缓解21例（61．7％），稳定8例（23．5％），进展4例（14．2％）。AFP下降〉50％者20例（58．8％），肝区疼痛、腹水、食欲、体力情况改善率分别为88．2％、44．4％、55．9％、32．0％；中位随访时间281d（63～558d），中位无进展生存时间118．5d（95％CI=88．8～148．2d）；Ⅲ～Ⅳ级不良反应发生率较低，仅有4例病人出现Ⅲ级胃肠反应，2例病人出现Ⅲ级白细胞减少。结论TACE联合含洛铂方案治疗不可切除原发性肝癌效果确切，不良反应轻，值得临床推广应用。Objective To observe the effect and safety of lobaplatin combined with floxuridine/pirarubicin in transcatheter hepatic arterial ehemoembolization （TACE） on unresectable primary liver cancer. Methods TACE with lobapiatin/floxuridine/pirarubicin was used to treat 34 patients with unreseetable primary liver cancer. Blood routine examination, liver function tests, AFP and iconography were carried out 4--6 weeks after therapy, the efficacy was evaluated, and the next cycle of therapy was made according to the results. A regular follow-up was conducted. Results Of the 34 patients, one （2.9%） with complete remission, 21 （61.7%） with partial remission, eight （23.5%） with stable eondition, and four with progression. The content of AFP dropped by over 50%/00 in 20 （58.8%） patients. The improvement of hepatalgia （88.2%）, ascites （44.4%）, appetite （55.9%）, and physical strength （32.00/00） was observed. The median follow-up time （MFT） was 281 days （63--558 days）, the median pro- gression-free survival was 118.5 days （95 % C1：88.8--148.2days）. Adverse reactions （ Ⅲ～Ⅳgrade） were less commora, only four patients presented vomiting and two showed grade-IlI thrombocytopenia. Conclusion Transcatheter hepatic arterial cbemoem- bolization with Lobaplatin/floxuridine/pirarubicin is an effective and safe treatment for primary liver cancer with less adverse reactions.

关 键 词：癌 肝细胞 洛铂 栓塞 治疗性 化学疗法 肿瘤 局部灌注 放射学 介入性 

分 类 号：R735.7[医药卫生—肿瘤]