血清HE4、TSGF和CA125联合检测诊断卵巢癌的价值  

Application value of combined detection of serum HE4, TSGF and CA125 in the diagnosis of ovarian cancer

作　　者：范群[1] 李玉芳[1] 范姜铱柔 郭端英[1] 束振华[2] 

机构地区：[1]深圳市龙岗中心医院妇科,广东深圳518116 [2]深圳市龙岗中心医院检验科,广东深圳518116

出　　处：《海南医学》2015年第11期1634-1636,共3页Hainan Medical Journal

基　　金：深圳市龙岗区2012年度科技计划项目(编号:YS2012207)

摘　　要：目的探讨血清人附睾蛋白4(HE4)、肿瘤特异性生长因子(TSGF)和肿瘤抗原(CA125)联合检测对卵巢癌的诊断价值。方法选取卵巢癌患者70例为研究对象,另选择60例卵巢良性肿瘤患者为对照组,检测并比较卵巢良性肿瘤、卵巢癌Ⅰ期及卵巢癌Ⅱ、Ⅲ期间HE4、CA125及TSGF水平的差异。观察HE4、CA125及TSGF与卵巢癌侵袭性关系(周围浸润、淋巴结转移及复发),并分析单项指标及联合应用对卵巢癌诊断的敏感性、特异性、阳性预测值、阴性预测值及诊断效率。结果卵巢良性肿瘤、卵巢癌Ⅰ期及卵巢癌Ⅱ、Ⅲ期三组比较,HE4、CA125及TSGF呈递增趋势,且三组间比较差异具有统计学意义(P<0.05)。与不伴有周围浸润、淋巴结转移及复发的卵巢癌比较,存在周围浸润、淋巴结转移及复发的卵巢癌患者HE4、CA125及TSGF水平均显著升高,差异具有统计学意义(P<0.05)。单项比较,CA125诊断敏感性最高,HE4诊断特异性及诊断效率最高。与单项指标比较,联合检测的敏感性、阳性预测值、阴性预测值及诊断效率更高,且差异具有统计学意义(P<0.05)。结论血清HE4、TSGF和CA125联合检测对卵巢癌诊断效率高,值得临床推广应用。Objective To explore the diagnostic efficiency of combined detection of serum human epididymis protein 4 （HE4）, tumor specific growth factor （TSGF） and cancer antigen 125 （CA125） in ovarian cancer. Methods Sev-enty patients with ovarian cancer were selected as the research objects, and sixty patients with benign ovarian tumor were enrolled as the control group. The difference in HE4, CA125 and TSGF levels were analyzed among benign ovarian tu-mor, phaseⅠovarian cancer, phaseⅡ-Ⅲovarian cancer. Relations between HE4, CA125, TSGF and ovarian cancer invasiveness （surrounding invasion, lymph node metastasis and relapse） were observed. The effects of single detection （using one index） and combined detection （combined application of the indexes for detection） on the sensitivity, speci-ficity, positive predictive value, negative predictive value and diagnostic efficiency in the diagnosis of ovarian cancer were analyzed. Results HE4, CA125 and TSGF increased successively in benign ovarian tumor, phaseⅠovarian can-cer, phase Ⅱ-Ⅲ ovarian cancer, and the differences among the three groups were statistically significant （P〈0.05）. HE4, CA125 and TSGF levels of patients with ovarian cancer invasion, lymph node metastasis and recurrence were significantly elevated （P〈0.05）. In comparison of single index, CA125 had the highest sensitivity of diagnosis, and HE4 had the highest specificity and diagnostic efficiency. Compared with single detection, combined detection results in significantly higher sensitivity, positive predictive value, negative predictive value, and diagnostic efficiency （P〈0.05）. Conclusion Combined detection of serum HE4, TSGF and CA125 have high efficiency in the diagnosis of ovarian cancer. It is worthy of clinical application.

关 键 词：HE4 卵巢癌 卵巢肿瘤 肿瘤特异性生长因子 肿瘤抗原 

分 类 号：R737.31[医药卫生—肿瘤]