不同分期大肠癌组织中VEGF、CEA、Endostatin的表达及其与肝转移的关系  

Expression of vascular endothelial growth factor, carcino-embryonic antigen, Endostatin in different stages of colorectal cancer and their correlations with hepatic metastasis

作　　者：夏翠锋[1] 李强[1] 沈焘[1] 程先硕[1] 李云峰[1] 

机构地区：[1]云南省肿瘤医院大肠癌中心,云南昆明650000

出　　处：《海南医学》2015年第12期1722-1724,共3页Hainan Medical Journal

基　　金：国家自然科学基金(编号:30960445)

摘　　要：目的探讨血管内皮生长因子（VEGF）、癌胚抗原（CEA）、内皮抑素（Endostatin）在不同分期大肠癌中的表达及其与肝转移的关系。方法选取我院大肠癌手术患者116例,术中采集大肠癌组织（癌症组,116例）和癌旁正常大肠组织（正常组,100例）,采用免疫组织化学方法检测VEGF、CEA、Endostatin表达情况,比较三者在不同临床分期大肠癌中的表达及其与肝转移的相关性。结果癌症组VEGF、CEA阳性率明显高于正常组,Ⅲ-Ⅳ期大肠癌组织VEGF、CEA阳性率明显高于Ⅰ-Ⅱ期,比较差异均具有统计学意义（P〈0.05）;癌症组Endostatin阳性率明显低于正常组,Ⅲ-Ⅳ期大肠癌组织Endostatin阳性率明显低于Ⅰ-Ⅱ期,比较差异均具有统计学意义（P〈0.05）。同时性肝转移者VEGF、CEA阳性率明显高于无肝转移者,Endostatin阳性率明显低于异时性肝转移和无肝转移者,异时性肝转移者CEA阳性率明显高于无肝转移者,差异均具有统计学意义（P〈0.05）。结论 VEGF、CEA在大肠癌组织中显著高表达,Endostatin在大肠癌组织中显著低表达,其中临床分期越高,合并肝转移,VEGF、CEA阳性率越高,Endostatin阳性率越低,三者表达在评估临床分期、肝转移类型中具有重要价值。Objective To investigate the expression of vascular endothelial growth factor （VEGF）, carci-no-embryonic antigen （CEA）, Endostatin in different stages of colorectal cancer and their correlations with hepatic me-tastasis. Methods A total of 116 patients of colorectal cancer were selected in our hospital. Samples were collected from colorectal cancer tissues （cancer group, n=116） and the adjacent normal colon tissues （normal group, n=100）. The expression of VEGF, CEA, Endostatin were detected by immunohistochemical method, and then compared be-tween different clinical stages. Their correlations with hepatic metastasis were analyzed. Results The positive expres-sion rate of VEGF, CEA were significantly higher in cancer group than normal group, and also inⅢ-Ⅳstage colorec-tal cancer thanⅠ-Ⅱstage colorectal cancer, with statistically significant differences （P〈0.05）. The positive expres-sion rate of Endostatin were significantly lower in cancer group than normal group, and also inⅢ-Ⅳstage colorectal cancer thanⅠ-Ⅱstage colorectal cancer, with statistically significant differences （P〈0.05）. The positive expression rate of CEA, VEGF were significantly higher in patients with synchronous hepatic metastasis than those without hepat-ic metastases;the positive expression rate of Endostatin was significantly lower in patients with synchronous hepatic metastasis than those with metachronous hepatic metastasis and those without hepatic metastasis;the positive expres-sion rate of CEA was significantly higher in patients with metachronous hepatic metastasis than those without hepatic metastasis. The differences were all statistically significant （P〈0.05）. Conclusion VEGF, CEA show significantly in-creased expression in colorectal cancer tissues, and Endostatin has significantly lowered expression in colorectal can-cer tissues. With the development of clinical stage or the complication of hepatic metastasis, the positive expression rates of CEA, VEGF increase and the positive expr

关 键 词：血管内皮生长因子 癌胚抗原 内皮抑素 大肠癌 肝转移 

分 类 号：R735.34[医药卫生—肿瘤]