AEG －1、MMP －9在结直肠组织中的表达及临床病理相关性的研究  

Study on the association between expression and clinicopathological significance of AEG-1 and MMP-9 in colorectal tissue

作　　者：宋鸿涛[1] 秦誉[1] 李聪[1] 姚国栋[1] 王恕怀[1] 耿敬姝[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院病理科,哈尔滨150081

出　　处：《实用肿瘤学杂志》2015年第3期197-202,共6页Practical Oncology Journal

基　　金：基金项目：黑龙江省教育厅资助项目（12511175）

摘　　要：目的：探讨星形细胞上调基因1（AEG－1）和基质金属蛋白酶9（MMP－9）在结直肠组织中的表达并分析其与结直肠癌的临床病理因素之间的相关性。方法应用免疫组化技术检测AEG－1和MMP－9在结直肠正常黏膜（45例）、低级别腺瘤（31例）、高级别腺瘤（15例）和结直肠癌（146例）中的表达，并分析其表达的意义。结果 AEG－1在结直肠正常黏膜、低级别腺瘤、高级别腺瘤和结直肠癌中有逐步升高的趋势。 MMP－9表达与AEG－1有类似的趋势。 AEG－1在结直肠癌组织中的阳性表达率与临床分期、T分期、N分期、M分期及组织分化有统计学差异（P＜0．05），而与年龄、性别、肿瘤位置和肿瘤大小无统计学差异（P＞0．05）。在结直肠癌中，AEG－1和MMP－9表达呈显著正相关，AEG－1、MMP－9高表达的患者具有较短的生存期（P＜0．05）。结论 AEG－1参与结直肠癌的发生，与结直肠癌的演进相关，并可能作为结直肠癌患者预后的一种新的生物标志物。Objective To investigate the expression of astrocyte elevated gene -1（ AEG-1） and matrix metallopeptidase 9（MMP-9）in colorectal tissues and evaluate its correlation with clinical pathologic factors of colorectal cancer.Methods AEG-1 and MMP-9 expression in normal colorectal mucous （n=45）,low-grade adenoma（n=31）,high-grade adenoma（n=15）and colorectal carcinoma（n=146）were examined by immuno-histochemistry .Statistical analyses were applied to test the significance of its expression .Results AEG-1 ex-pression levels were gradually elevated in normal tissues ,low-grade adenoma ,high-grade adenoma and colorec-tal carcinoma respectively .Furthermore ,there was a similar trend for MMP -9from normal mucous to adenoma and carcinoma .Statistical analysis revealed that AEG -1 expression was markedly correlated with the UICC stage,T classification,N classification,M classification,and histological differentiation in the colorectal cancer pa-tients,but not with age,gender,tumor location and tumor size.In addition,AEG-1 expression was positively cor-related with the MMP-9 expression in colorectal cancer .Besides,those patients with high AEG-1 and MMP-9 levels had shorter survival time （ P〈0 .05 ） .Conclusion AEG-1 may be involved in carcinogenesis and pro-gression of colorectal carcinoma and can be a novel prognostic biomarker in patients with colorectal carcinoma .

关 键 词：星形细胞上调基因1 基质金属蛋白酶9 结直肠癌 结直肠腺瘤 

分 类 号：R735.34[医药卫生—肿瘤]