IGF－1R和IRS－1在肺鳞癌组织中的表达及临床意义  

Expressions and clinical significances of IGF-1R and IRS-1 in squamous cell lung cancer

作　　者：刘亚楠[1] 陈莉娜[1] 张静[1] 周永芳[1] 李晓莉[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院内一科,哈尔滨150081

出　　处：《实用肿瘤学杂志》2015年第3期225-230,共6页Practical Oncology Journal

摘　　要：目的：检测胰岛素样生长因子1受体（IGF－1R）和胰岛素受体底物1（IRS－1）在肺鳞癌组织中的表达，探究其在肺鳞癌发生发展中的作用及临床意义。方法采用免疫组化法检测246例肺鳞癌组织与40例癌旁正常组织中IGF－1R、IRS－1的表达情况，并分析两者的相关性及与临床病理特征和预后的关系。结果 IGF －1R 在肺鳞癌组织中的阳性表达率明显高于癌旁组织，其表达率分别为54．07％和32．5％，IRS－1在肺鳞癌组织中的阳性表达率明显低于癌旁组织，其表达率分别为38．21％和70％，各组间差异均有统计学意义（P＜0．05）。 IGF－1R的表达与淋巴结转移相关（P＜0．05），IRS－1的表达与肺鳞癌组织的分化程度、淋巴结转移相关（P＜0．05）。 IGF－1R阳性表达组患者的生存期明显短于IGF－1R阴性表达组患者，IRS－1阳性表达组患者的生存期明显长于IRS－1阴性表达组患者，差异有统计学意义（P＜0．001，P＜0．05）。 IGF－1R与IRS－1在肺鳞癌组织中的表达呈负相关（r＝－0．125，P＜0．001）。结论 IGF－1R、IRS－1都参与了肺鳞癌的发生、发展，且IGF－1R为独立预后因子。Objective The aim of the study is to detect the expression of IGF -1R and IRS-1 in squa-mous cell lung cancer （ SQCLC） and to explore the role in the development of squamous cell lung cancer and clini -cal significance .Methods Specimens from 246 surgical SQCLC and 40 adjacent normal lung tissues were evalu-ated for IGF-1R and IRS-1 expression by immunohistochemistry .We explored the correlation between IGF -1R and IRS-1,their relationship with clinicopathological parameters and their impact on outcome in SQCLC pa -tients.Results SQCLC of IGF -1R positive expression rate was 54.07%,which was higher than in adjacent normal tissue（32.5%）,SQCLC of IRS-1 positive expression rate was 38.21%,which was lower than in adja-cent normal tissue（70%）,the pairwise difference was statistically significant （P〈0.05）;Expression of IGF-1R was correlated with lymph node metastasis （P〈0.05）,IRS-1 expression was related with degree of differentia-tion and lymph node metastasis （P〈0.05）.Survival of IGF -1R expression group of patients was significantly shorter than the expression of IGF -1R negative patients ,the survival of the IRS-1 expression was significantly longer than patients who negatively expressed IRS -1,the difference was statistically significant （P=〈0.001 and=0.021）.IGF-1R was negatively correlated with IRS -1 expression in SQCLC（r=-0.125,P〈0.001）. Conclusion IGF-1R,IRS-1 are involved in the occurrence of SQCLC ,the development .The IGF-1R is an independent prognostic factor in SQCLC .

关 键 词：IGF-1R IRS-1 肺肿瘤 鳞癌 

分 类 号：R734.2[医药卫生—肿瘤]