1-十一烯酰溶血磷脂的选择性合成与表征  

Selective synthesis and characterization of 1-undecenoyl-sn-glycero-3-phosphocholine

作　　者：刘杨静 胡志雄[1,2] 余小波[1] 齐玉堂[1] 张维农[1,2] 

机构地区：[1]武汉轻工大学食品科学与工程学院,湖北武汉430023 [2]农产品加工湖北省协同创新中心,湖北武汉430023

出　　处：《武汉轻工大学学报》2015年第2期55-59,69,共6页Journal of Wuhan Polytechnic University

基　　金：湖北省自然科学基金项目(2014CFB885);国家自然科学基金项目(31371783);国家粮食公益性行业科研专项(2013007);武汉轻工大学研究生教育创新计划项目(2013cx017)

摘　　要：旨在建立一种选择性合成1-十一烯酰溶血磷脂的有效方法与途径。二丁基氧化锡与甘油磷脂酰胆碱形成复合物,在异丙醇溶剂体系中与十一烯酰氯反应,选择性合成得到1-十一烯酰溶血磷脂。产物纯化后经高效液相色谱、红外光谱、电喷雾电离质谱等手段进行表征。产物经表征后确证为1-十一烯酰溶血磷脂,且反应的选择性可达90%以上。该方法成本低廉、操作简便、条件温和、易纯化且得率高,所得产物1-十一烯酰溶血磷脂的结构中含有"点击反应"活性的端烯基,在生物、医药、高分子、材料等领域中具有重要应用价值与潜力。To establish a method for the selective synthesis of 1-undecenoyl-sn-glycero-3-phosphocholine.A practi-cal selective synthesis of 1-undecenoyl-sn-glycero-3-phosphocholine has been established through the selective acy-lation of the complex of L-α-Glycerophosphorylcholine and dibutyltin oxide （ DBTO） by undecenoate chloride.The purified product has been analyzed and identified by high performance liquid chromatography （ HPLC ） , infrared spectrum （ IR） and electrospray ionization mass spectrum （ ESI-MS） .The product has been proved to be 1-unde-cenoyl-sn-glycero-3-phosphocholine, and the selectivity of reaction up to 90%.The proposed method can provide many advantages such as low cost, simple operation, mild reaction conditions, high yield and easy product purifica-tion process.The product 1-undecenoyl-sn-glycero-3-phosphocholine contains a “click chemistry” active alkenyl group which will guarantee its wide application value and potential in the field of biology, medicine, polymer and materials.

关 键 词：1-十一烯酰溶血磷脂 合成 甘油磷脂酰胆碱 二丁基氧化锡 

分 类 号：TQ031.2[化学工程]