头颈部肿瘤放疗中转化医学相关机制的研究进展  

Development in translational medicine-related mechanisms of radiotherapy for head and neck cancer

作　　者：贾立立[1] 孟粹达[2] 刘晓冬[1] 马淑梅[1] 

机构地区：[1]吉林大学公共卫生学院放射生物学教研室、卫生部放射生物学重点实验室,长春130021 [2]吉林大学中日联谊医院耳鼻咽喉-头颈外科,长春130033

出　　处：《国际放射医学核医学杂志》2015年第3期247-251,共5页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家自然科学基金（31370837）;吉林大学基本科研业务费（201103082）

摘　　要：头颈部肿瘤是目前世界上最常见的肿瘤之一，超过90%的头颈部肿瘤为鳞状细胞癌。放疗在头颈部肿瘤的治疗中显得尤为重要，目前国内治疗早期肿瘤可以单纯放疗为主，晚期肿瘤则选择综合性治疗。转化医学是近些年来新的研究重点，将科研过程及其成果与临床紧密结合，尤其体现在通过检测患者肿瘤组织中的基因突变靶点及基因单核苷酸多态性分型、mRNA基因定量表达，为临床提供靶向及个体化放疗的依据，能显著提高治疗的有效率。Head and neck cancer is currently one of the most common tumors worldwide. More than 90%of head and neck tumors are squamous cell carcinoma. Radiotherapy is particularly important in the treatment of head and neck cancer. Current domestic treatment is sole radiotherapy for early tumors, but comprehensive treatment is administered for late tumors. Translational medicine, which closely connects results from studies and clinical medicine, has emerged as a new research focus in recent years. This method is expected to provide basis for target and individual radiotherapy through the detection of target gene mutations, gene single nucleotide polymorphism classification, and mRNA gene expression in tumor tissues of patients. Thus, this method can be used to evidently improve the efficiency of clinical treatment of tumors.

关 键 词：头颈部肿瘤 肿瘤 鳞状细胞 放射疗法 转化医学 

分 类 号：R730.55[医药卫生—肿瘤] R739.91[医药卫生—临床医学]