Pygopus研究进展  

Recent advance in Pygopus

作　　者：李明聪[1] 王占祥[1] 

机构地区：[1]厦门大学附属第一医院神经外科,361003

出　　处：《国际肿瘤学杂志》2015年第5期364-366,共3页Journal of International Oncology

基　　金：国家自然科学基金（81271332）;福建省自然科学基金（2009D002）

摘　　要：Pygopus（Pygo）是Wnt信号通路中新发现的成员，位于该信号通路核心蛋白β-连接蛋白（β-catenin）下游，可介导β-catenin 入核，激活下游靶基因转录。Pygo对哺乳动物的胚胎发育及肿瘤的形成起着重要的作用。研究表明，Pygo通过组蛋白解读、组蛋白修饰等表观遗传学机制调控干细胞、肿瘤细胞、肿瘤干细胞。阐述Pygo蛋白在其中的作用及机制，将会加深对与该蛋白相关肿瘤的认识。Pygopus（Pygo）is a new discovered component of Wnt signaling,which is located in the downstream of its core protein β-catenin and can mediate β-catenin into nucleus and activate target gene tran-scription. Pygo plays an important role in mammalian embryonic development and tumor formation. Recent studies show that Pygo regulates stem cells,tumor cells and tumor stem cells by epigenetic mechanisms such as histone interpretations and modifications. Further insights into Pygo′s functions and mechanisms will extend our knowledge of the Pygo-related tumors.

关 键 词：肿瘤干细胞 后成说 遗传 Pygopus 

分 类 号：R730.2[医药卫生—肿瘤]