CEA、CYFRA21-1联合检测在非小细胞肺癌诊断中的价值  

Diagnostic value of CEA and CYFRA21-1 combined examination for non-small cell lung cancer

作　　者：李乃庆 彭玲[1] 莫艳萍[1] 罗丽琼[1] 

机构地区：[1]柳州市柳铁中心医院呼吸内科,545007

出　　处：《国际呼吸杂志》2015年第12期892-895,共4页International Journal of Respiration

摘　　要：目的：用绘制ROC曲线的方法评价癌胚抗原（CEA）、细胞角蛋白19片段（CYFRA21-1）联合检测在非小细胞肺癌诊断的临床价值。方法收集78例确诊为非小细胞肺癌的患者及同期79例肺部良性疾病患者的临床资料,使用 SPSS 18.0软件绘制 ROC 曲线分析 CEA 及 CYFRA21-1联合检测诊断非小细胞肺癌的敏感性、特异性及诊断准确性,评价其在诊断非小细胞肺癌中的临床价值。结果非小细胞肺癌组血清 CEA、CYFRA21-1水平显著高于肺部良性病变组（P 〈0.01）。CEA 单独检测的敏感性为64.2%,特异性为97.5%,CYFRA21-1单独检测的敏感性为61.7%,特异性为88.6%,两者联合检测的敏感性为71.6%,特异性为83.5%,明显高于单项检测。两者联合检测的曲线下面积为0.802,高于 CEA、CYFRA21-1的 ROC 曲线下面积（0.760、0.792）。吸烟的男性患者中两者联合检测的曲线下面积为0.841,敏感性为69.2%,特异性为100.0%。结论 CEA、CYFRA21-1两者联合检测可提高对非小细胞肺癌诊断的敏感性,且对男性吸烟患者的诊断准确性最高,具有一定的临床价值。Objective To evaluate the clinical value of carcinoembryonic antigen （CEA）and cytokeratin 1 9 fragment antigen （CYFRA21-1）combined detection in the diagnosis of non-small cell lung cancer by ROC curve.Methods The clinical data of patients diagnosed with non-small cell lung cancer from January 1,2012 to December 1,2014 were collected,and the patients with lung benign disease were selected as control group to make statistical analysis on the levels of serum CEA,CYFRA21-1 of patients, and analyze the sensitivity,specificity,and accuracy of combined detection of CEA and CYFRA21-1 in the diagnosis of non-small cell lung cancer.Results The levels of CEA and CYFRA21-1 in serum of patients with lung cancer were significantly higher than those of patients with pulmonary benign lesions （P 〈0.01）.The sensitivity of CEA single detection was 64.2%,specificity was 97.5%.The sensitivity of CYFRA21-1 single detection was 61.7%,specificity was 88.6%.The sensitivity of combined detection was 71.6%,specificity was 83.5%,significantly higher than those of single detection.The area under ROC curve of CEA or CYFRA21-1 single detection was 0.760,0.792 respectively.The area under ROC curve of combined detection was 0.802.In smoking male patients,the area under ROC curve of combined detection was 0.841,sensitivity was 69.2%,specificity was 100.0%.Conclusions CEA and CYFRA21-1 combined detection can improve the sensitivity in the diagnosis of non-small cell lung cancer and has a certain clinical value.

关 键 词：非小细胞肺癌 癌胚抗原 细胞角蛋白19片段 ROC曲线 

分 类 号：R734.2[医药卫生—肿瘤]