与阿尔茨海默病相关的主观认知减退及生物标志物的研究进展  

The research progression of the subject cognitive decline associated with Alzheimer's disease and its biomarkers

作　　者：刘江红[1] 董静[1] 邢怡[1] 

机构地区：[1]首都医科大学宣武医院神经内科,北京100053

出　　处：《中国医药导报》2015年第18期30-34,38,共6页China Medical Herald

基　　金：国家自然科学基金资助项目(81301208);教育部高等学校博士学科点专项科研基金(20131107120002);首都医科大学基础临床合作项目(13JL70)

摘　　要：阿尔茨海默病是发生在老年人群中的常见痴呆类型,其进程是连续性的,包括临床前期、轻度认知障碍期和痴呆期。痴呆期的患者其日程生活能力受损,药物治疗效果不理想,因此早期诊断和干预是至关重要的。利用生物标志物在临床前期即主观认知减退期的研究取得了一些进展,本文对于主观认知减退及其生物标志物的研究进行综述。Alzheimer＆#39;s disease is a common dementia among aged population. The course of Alzheimer＆#39;s disease is continuous which includes preclinical phase, mild cognitive impairment phase and dementia phase. If the patients are in dementia phase, their daily activity impaired, and the effects of medicine treatment are not obvious. It is important to diagnose and postpone the course of Alzheimer＆#39;s disease. There are some progression of the biomarker in subjective cognitive decline. We reviewed the subject cognitive decline and its biomarkers in this article.

关 键 词：主观认知减退 阿尔茨海默病 生物标志物 多模态磁共振 

分 类 号：R749.16[医药卫生—神经病学与精神病学]