生物免疫疗法联合放化疗治疗局限期小细胞肺癌的随机对照研究  

Biological Immunotherapy Combined With Radiation and Chemotherapy for Limited Small Cell Lung Cancer: A Randomized Controlled Trial

作　　者：苗学红 王淑玲[2] 

机构地区：[1]郑州大学第一附属医院中西医结合科,河南省郑州市450052 [2]郑州大学基础医学院

出　　处：《中国全科医学》2015年第18期2122-2126,共5页Chinese General Practice

基　　金：河南省科技厅科技攻关项目(112300410049)

摘　　要：目的探讨自体多种细胞因子诱导的杀伤细胞(CIK)生物免疫疗法联合放化疗治疗局限期小细胞肺癌(SCLC)的临床疗效。方法选取2007年1月—2010年2月于郑州大学第一附属医院收治的局限期SCLC患者60例为研究对象,采用随机数字表法分为观察组和对照组,每组各30例。对照组采用同期放化疗方案,观察组采取与对照组相同的放化疗方案,放化疗结束后采用自体多种细胞因子诱导的CIK生物免疫疗法。评价患者近期疗效、生活质量改善情况、1年和2年生存概率及毒副作用发生情况。结果对照组完全缓解(CR)0例、部分缓解(PR)15例、稳定(SD)1例、进展(PD)14例,观察组CR 2例、PR 19例、SD 3例、PD 6例,两组近期疗效不同(u=2.058,P<0.05);观察组疾病控制率为80.0%(24/30),高于对照组的53.3%(16/30)(χ2=4.800,P=0.028)。两组患者生活质量改善程度不同(u=-4.138,P<0.01)。观察组白细胞计数(WBC)减少发生率为50.0%(15/30),低于对照组的80.0%(24/30)(χ2=5.934,P<0.05)。对照组、观察组1年生存概率分别为76.7%(23/30)、83.3%(25/30),2年生存概率分别为73.9%(17/23)、88.0%(22/25),差异无统计学意义(P>0.05)。结论生物免疫疗法联合放化疗能有效提高局限期SCLC患者疾病控制率,改善生活质量,降低部分毒副作用的发生。Objective To explore clinical effect of the therapeutics of Cytokine - induced Killer（ CIK）cell in combination with radiation and chemotherapy on limited stage small cell lung cancer（SCLC）. Methods From January 2007 to February 2010,in the First Affiliated Hospital of Zhengzhou University,60 SCLC patients were divided randomly into observation group and control group,30 in each. Control group were given concurrent chemotherapy,observation group were given the same chemotherapy,followed by CIK immunotherapy. The short - term therapy,improvement of life of quality（LOQ）,1 - year,2- year survival probabilities and adverse reactions were evaluated. Results The numbers of CR,PR,SD,and PD were 0,15, 1,and 14 in control group,while the numbers of CR,PR,SD,and PD were 2,19,3,6 in observation group. The curative effects were different between 2 groups（u = 2. 058,P 0. 05）. Conclusion Biological immune therapy combined with radiation and chemotherapy can improve the control rates of limited SCLC patients,improve their QOL,reduce incidence of part adverse reactions.

关 键 词：小细胞肺癌 免疫疗法 化放疗 生活质量 药物毒性 随机对照试验 

分 类 号：R734.2[医药卫生—肿瘤]