肿瘤血管多样性的形成及其研究意义  

Diversity of Tumor Angiogenesis and Its Significance

作　　者：赵文静[1] 杨俐萍[1] 

机构地区：[1]南通大学附属肿瘤医院肿瘤研究所,江苏南通226361

出　　处：《肿瘤学杂志》2015年第6期507-511,共5页Journal of Chinese Oncology

基　　金：国家自然科学基金面上项目(81272378)

摘　　要：恶性肿瘤的快速生长、转移与血管密切相关。大量研究表明,肿瘤血管生成细胞的来源存在多源性,血管生成的过程呈多样性,血管生成的调节呈多靶点性。这些特征提示研究者需拓宽思路,从不同层面理解肿瘤的新生血管生成机制,进而为寻找高度选择性血管靶点的临床抗肿瘤药物提供新的思路。Tumor angiogenesis contributes to tumor growth and metastasis. A number of studies indicate that tumor angiogenesis is a very complex process,in which multiple cellular origin and vasculogenic mimicry are involved. The vessels in tumor tissue,comparing to the normal ones,are heterogeneity in both of the structure and bio-characteristics. More and more targets on blood vessels have been discovered. The complexity of tumor angiogenesis may provide new insight into developing new targeted therapies of cancer.

关 键 词：肿瘤血管生成 血管生成拟态 肿瘤微血管构筑表型异质性 

分 类 号：R73[医药卫生—肿瘤]