顺铂胸腔灌注联合化疗治疗肺癌并恶性胸水的疗效观察  

Clinical Effect of Lung Cancer With Malignant Pleural Effusion in Cisplatin Pleural Perfusion Combined With Chemotherapy Treatment

作　　者：边志民[1] 

机构地区：[1]中国医学科学院肿瘤医院综合科,北京100029

出　　处：《中国卫生标准管理》2015年第16期99-101,共3页China Health Standard Management

摘　　要：目的探讨对肺癌恶性胸水患者采用顺铂（cisplatin,DDP）胸腔灌注联合化疗的临床效果。方法随机收集我院于2013年1月∽2014年12月收治肺癌恶性胸水60例,分为观察组与对照组,各30例,对照组给予全身化疗治疗,观察组在全身化疗的基础上联合DDP胸腔灌注治疗,比较两组患者的结果。结果观察组的总有效率为90.00%,高于对照组的66.67%,差异有统计学意义（P〈0.05）;观察组的骨髓抑制、胃肠道反应、肾脏毒性、神经毒性发生率分别为33.33%、26.67%、23.33%、13.33%,均略高于对照组的26.67%、20.00%、20.00%、10.00%,差异无统计学（P〉0.05）。结论对肺癌并恶性胸水患者采用DDP胸腔灌注联合化疗,能有效减少恶性胸水及改善患者的临床症状,且毒副反应较轻,患者耐受性较好,安全有效。Objective In this study, we investigated the clinical effect on lung cancer patients with malignant pleural effusion in cisplatin（DDP） pleural perfusion combined chemotherapy treatment. Methods We collected 60 cases of lung cancer with malignant pleural effusion in our hospital from January 2013 to December 2014 at random. All of the patients were divided into observation group and control group. Each group included 30 cases. Systemic chemotherapy treatment was given in control group, while observation group had the basic systemic chemotherapy combined DDP pleural perfusion treatment. Then we compared the results of different treatment strategy. Results The total effective rate of observation group was 90.00%, significantly higher than that of control group which was 66.67%. The difference was statistically significant（P〈0.05）. Incidence of marrow depression, gastrointestinal tract reaction, renal toxicity, and neurotoxicity were 33.33%, 26.67%, 23.33% and 13.33% in observation group, while 26.67%, 20.00%, 26.67% and 20.00% in control group, respectively. However, this difference did not reach statistical significance in two groups（P〈0.05）. Conclusion DDP pleural perfusion combined chemotherapy treatment can effectively reduce malignant pleural effusion and improve the clinical symptoms of lung cancer patients. In addition, lighter side reaction and better tolerance are shown in patients received the effective treatment. In summary, due to its safety and effectiveness, this effective treatment strategy should be popularized.

关 键 词：肺癌 恶性胸水 胸腔灌注 顺铂 

分 类 号：R734.2[医药卫生—肿瘤]