改良根治术及保乳术治疗早期乳腺癌的对比研究  

Effect comparison between modified radical surgery and breast-conserving surgery in treating early breast cancer

作　　者：王斌 付肥郭 王学究[2] 张培新[2] 

机构地区：[1]安徽省第二人民医院普外科,安徽合肥200041 [2]安徽省阜阳市人民医院普外科,安徽阜阳236000

出　　处：《实用临床医药杂志》2015年第13期47-49,共3页Journal of Clinical Medicine in Practice

基　　金：中国高校医学期刊临床专项资金(11522814)

摘　　要：目的 对比改良根治术和保乳手术治疗早期乳腺癌的疗效和安全性。方法 将67例TNM分期为Ⅰ~Ⅱ期的乳腺癌患者根据具体病情及个人意愿分为根治术组32例和保乳手术组35例,根治术组行乳腺癌改良根治术,保乳手术组行保乳手术。结果 2组术后并发症差异无统计学意义（P〉0.05）。术后6个月保乳手术组乳腺癌治疗功能评价量表（FACT-B）各项评分均高于根治术组（P〈0.05或P〈0.01）。随访至2015年1月,根治术组和保乳手术组局部复发分别为2例（6.25%）和3例（8.57%）,远处转移分别为4例（12.50%）和3例（8.57%）,3年总生存率分别为93.75%（30/32）和94.29%（33/35）,5年总生存率分别为87.50%（28/32）和85.71%（30/35）。2组比较,差异均无统计学意义（P〉0.05）。结论改良根治术和保乳手术治疗早期乳腺癌的术后并发症、远期疗效相似,但行保乳手术的患者术后生存质量更高,临床应根据病情和患者意愿灵活选择术式。Objective To compare the clinical efficacy and safety of modified radical surgery and breast-conserving surgery in the treatment of patients with early breast cancer. Methotis A total of 67 patients with breast cancer with TNM stage Ⅰ - Ⅱ were divided into radical surgery group （ n = 32） treated with modified radical surgery for breast cancer and breast-conserving surgery group （ n = 35） with breast-conserving surgery, according to the specific disease conditions and the patients＇ intentions. Results There was no significant difference between two groups in postoperative complications （P 〉 0.05）. 6 months after operation, Functional Assessment of Cancer Therapy-Breast （FACT-B） index scores were significantly higher in breast-conserving surgery group than in radical surgery group （P〈0.05 or P〈0.01）. The follow up was ended in January, 2015, and the recurrent rates of radical surgical group and breast-conserving surgery group were 6.25% （2/32） and 8.57% （3/53）, distant metastatic rates were 12.50% （4/52） and 8.57% （3/53）, 3-year survival rates were 93.75% （30/32） and 94.29% （33/35） and 5-year survival rates were 87.5 % （28/32） and 85.71% （30/35） respectively, but there were no significant differences （P 〉0.05）. Conclusion Modified radical surgery has similar postoperative complications and long-term clinical efficacy to breast-conserving surgery, but the latter opertion is higher in the postoperative survival quality, so the surgical method should be carefully selected according to the disease conditions and the intentions of patients with early breast cancer.

关 键 词：乳腺癌 改良根治术 保乳手术 生存率 生存质量 

分 类 号：R737.9[医药卫生—肿瘤]