自拟益气养阴解毒汤联合GP方案化疗治疗晚期非小细胞肺癌疗效观察  

Curative Effect of Compound Poria Oral Liquid Combined with Chemotherapy of GP Regimen in Treatment of Advanced non Small Cell Lung Cancer

作　　者：王艳春[1] 程俊[2] 

机构地区：[1]中国人民解放军第二炮兵总医院,北京100088 [2]重庆市中医院,重庆400021

出　　处：《中国中医急症》2015年第5期851-853,共3页Journal of Emergency in Traditional Chinese Medicine

基　　金：基金项目:国家中医药管理局中西医结合重点建设专科

摘　　要：目的探讨自拟益气养阴解毒汤联合GP方案化疗治疗晚期非小细胞肺癌(NSCLC)的临床疗效。方法将98例患者随机分为对照组和观察组各49例,对照组给予GP方案(吉西他滨+顺铂)化疗,观察组给予GP方案化疗联合自拟益气养阴解毒汤治疗,对比两组疗效及安全性。结果观察组总有效率63.27%和临床获益率89.79%均分别优于对照组的32.65%和67.35%(均P<0.05)。两组治疗前中医证候评分、生活质量(SF-36)、KPS评分差别不大(均P>0.05)。两组治疗后中医证候评分、生活质量(SF-36)、KPS评分与治疗前比较,均明显改善(均P<0.05),且观察组中医证候评分、生活质量(SF-36)、KPS评分改善均优于对照组(均P<0.05)。两组治疗前CD3+、CD4+、CD8+、CD4+/CD8+、NK/%均差别不大(均P>0.05)。治疗后两组患者外周血CD3+、CD4+、CD8+、CD4+/CD8+、NK/%与治疗前比较,均明显上升(均P<0.05),且观察组改善优于对照组(均P<0.05)。观察组不良反应程度评分低于对照组(P<0.05)。结论 DP方案化疗基础上给予自拟益气养阴解毒汤辅助治疗晚期NSCLC可提高疗效,减少GP方案化疗毒副作用,充分调动机体自身免疫及抑瘤机能,改善晚期NSCLC患者中医证候、生活质量、体能状况。Objective： To investigate the compound Poria oral liquid combined with chemotherapy of GP regimen in treatment of advanced non small cell lung cancer（NSCLC） clinical curative effect. Methods： 98 cases of advanced NSCLC were randomly divided into control group and observation group with 49 cases in each group.The control group was given GP regimen（gemcitabine ＋ cisplatin） chemotherapy. Meanwhile,the observation group was given GP chemotherapy regimen combined with compound Poria oral liquid treatment. There were some indicators compared between two groups such as curative effect and safety. Results： The total effective rate in the observation group was 63.27% which was better than that of the control group with 32.65%. The clinical benefit rate in the observation group was 89.79% which was better than that of the control group with 67.35%. After treatment,these indices in 2 groups were improved obviously including the TCM syndrome score,the SF-36 score,the KPS score,CD3＋,CD4＋,CD8＋,CD4＋/CD8＋and NK（P〈0.05）. Moreover,these indicators improvements in the observation group were more significant that those in the control group（P〈0.05）. The adverse reaction score in the observation group was lower remarkably than that in the control group（P〈0.05）. Conclusion： Compound Poria oral liquid combined with chemotherapy of GP regimen in treatment of advanced NSCLC can reduce the toxic side effects of chemotherapy,improve the symptoms of patients and increase the curative effect of chemotherapy. It is worthy of promotion of further clinical study.

关 键 词：非小细胞肺癌 化疗 自拟益气养阴解毒汤 GP方案 

分 类 号：R743.2[医药卫生—神经病学与精神病学]