T2灌注加权成像联合DWI诊断乳腺良恶性病变  

T2 perfusion weighted imaging combined with DWI in diagnosis of benign and malignant breast lesions

作　　者：邓伟[1] 许泽兵[1] 曹骁[1] 

机构地区：[1]阆中市人民医院放射科,四川阆中637400

出　　处：《中国医学影像技术》2015年第6期863-866,共4页Chinese Journal of Medical Imaging Technology

摘　　要：目的探讨MR T2*PWI联合DWI对乳腺良恶性病变鉴别诊断价值。方法回顾性分析经手术病理证实的乳腺良恶性病变74例患者,共84个病灶,患者行常规MR平扫、T2*PWI和DWI检查。根据MR T2*首次通过灌注成像绘制时间-信号强度曲线,于ADC图测量病灶的ADC值;计算T2*PWI的最大下降线性斜率(MSD),并进行统计学分析。计算T2*PWI、DWI和两者联合对乳腺恶性病变的诊断效能。结果乳腺良恶性病变的MSD值、ADC值差异均有统计学意义(P均<0.05)。T2*PWI对乳腺恶性病变的诊断敏感度、特异度、阳性预测值、阴性预测值、ROC曲线下面积分别为90.57%(48/53)、83.87%(26/31)、90.57%(48/53)、83.87%(26/31)、0.87;DWI分别为84.91%(45/53)、74.19%(23/31)、84.91%(45/53)、74.19%(23/31)、0.83;两者联合分别为94.34%(50/53)、90.32%(28/31)、94.34%(50/53)、90.32%(28/31)、0.91。结论 T2*PWI联合DWI对乳腺良恶性病变具有较高的鉴别诊断价值。Objective To assess the diagnostic value of T2＊PWI combined with DWI in diagnosis of breast lesions.MethodsTotally 74 patients with 84 lesions confirmed pathologically were retrospectively analyzed.All patients underwent conventional MR scan,T2＊PWI and DWI.According to first-pass perfusion MR T2＊imaging rendered time-signal intensity curves,ADC value were measured;maximum slope of decrease（MSD）were calculated.The statistical analysis was performed.The diagnosis value of T2＊PWI,DWI,and their combination were also estimated.Results MSD and ADC between benign and malignant breast lesions were statistically significant（all P〈0.05）.In diagnosis of breast malignancy,the sensitivity,specificity,positive predictive value,negative predictive value,ROC area under the curve of T2＊PWI were 90.57%（48/53）,83.87%（26/31）,90.57%（48/53）,83.87%（26/31）,0.87,of DWI were 84.91%（45/53）,74.19%（23/31）,84.91%（45/53）,74.19%（23/31）,0.83,and of their combination were 94.34%（50/53）,90.32%（28/31）,94.34%（50/53）,90.32%（28/31）,0.91.Conclusion T2＊PWI combined with DWI has high differential diagnosis value for benign and malignant breast lesions.

关 键 词：乳腺肿瘤 扩散磁共振成像 灌注成像 

分 类 号：R737.9[医药卫生—肿瘤] R445.2[医药卫生—临床医学]