血浆巨噬细胞炎性蛋白与早期帕金森病的相关性  

Correlation between plasma macrophage inflammatory protein and early Parkinson＇s disease

作　　者：蒋倩雯[1] 马建芳[1] 陈生弟[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院神经内科,神经病学研究所,200025

出　　处：《中华神经科杂志》2015年第6期464-468,共5页Chinese Journal of Neurology

基　　金：国家重点基础研究发展计划资助项目（973计划,2011CB504104）;国家自然科学基金重点资助项目（81430022）;国家自然科学基金青年项目（81200979）

摘　　要：目的 检测早期帕金森病患者血浆巨噬细胞炎性蛋白lα（MIP-1α）和巨噬细胞炎性蛋白1β（MIP-1β）的水平,并探讨其与帕金森病运动、非运动症状的相关性.方法 研究对象为2013年1月28日至9月30日就诊于我院的59例早期原发性帕金森病患者（Hoehn-Yahr分级1.0 ～2.5级）以及54名同期健康对照者.采用酶联免疫吸附试验测定其血浆中MIP-1α和MIP-1β的浓度,采用统一帕金森病评定量表第三部分和Hoehn-Yahr分级在“开”期对帕金森病患者运动功能进行评估;用帕金森病非运动症状30问卷评估整体非运动功能损害;用简易精神状态检查量表评估认知功能损害;用帕金森病自主神经症状量表评估自主神经功能损害;用汉密尔顿抑郁量表评估抑郁症状;用快动眼睡眠行为障碍筛查问卷评估快动眼睡眠行为障碍,并用Spearman相关分析检验MIP-1 α和MIP-1β的浓度与各量表评价结果之间的相关性.结果 早期帕金森病患者和健康对照之间MIP-1 α及MIP-13水平差异无统计学意义,但MIP-lα与帕金森病的抑郁（汉密尔顿抑郁量表评分,r=-0.520,P=0.027）、快动眼睡眠行为障碍症状（快动眼睡眠行为障碍筛查问卷,r=-0.537,P=0.039）呈负相关.结论 早期帕金森病中MIP-1α可能与抑郁及快动眼睡眠行为障碍相关.Objective To detect the plasma macrophage inflammatory protein （MIP） levels in patients with early Parkinson＇ s disease （PD） and to investigate whether plasma MIP was associated with motor and non-motor symptoms in early PD.Methods Fifty-nine patients with early idiopathic PD （Hoehn-Yahr Staging Scale from 1.0 to 2.5） treated in our hospital from January 28,2013 to September 30,2013 and 54 healthy controls were recruited.Plasma MIP-1α and MIP-1β levels were measured by enzyme-linked immunosorbent assay.Motor function was assessed by Unified Parkinson＇ s Disease Rating Scale Part Ⅲ and Hoehn-Yahr Staging Scale during “on” period.Total non-motor symptoms were assessed by Non-motor Symptoms Questionnaire.Cognitive dysfunction was assessed by Mini Mental State Examination.Autonotic dysfunction was assessed by Scales for Outcomes in Parkinson＇ s disease-Autonomic.Depression was assessed by Hamilton Depressive Scale （HAMD）.Rapid eye movement （REM） sleep behavior disorder was assessed by REM sleep behavior disorder screening questionnaire （RBDSQ）.Correlation between plasma MIP levels and scale scores was analyzed by Spearman rank correlation.Results Plasma MIP-1o and MIP-1β levels were not significantly different between early PD patients and healthy controls.However,plasma MIP-1 α level negatively correlated with depression （HAMD score,r =-0.520,P =0.027） and rapid eye movement sleep behavior disorder （RBDSQ score,r =-0.537,P =0.039）.Conclusion MIP-1 α may be correlated with depression and RBD in early PD.

关 键 词：帕金森病 巨噬细胞炎性蛋白1Α 巨噬细胞炎性蛋白1β REM睡眠行为障碍 抑郁 

分 类 号：R742.5[医药卫生—神经病学与精神病学]