次级淋巴组织趋化因子在溃疡性结肠炎中的表达及其意义  

Expression and Significance of Secondary Lymphoid Tissue Chemokine in Ulcerative Colitis

作　　者：高东锋 周国雄[1] 曹维[1] 陈海琴[1] 张海峰[1] 

机构地区：[1]南通大学附属医院消化内科,226001 [2]陕西省咸阳市中心医院消化内科,712000

出　　处：《胃肠病学》2015年第5期297-299,共3页Chinese Journal of Gastroenterology

基　　金：南通市应用研究计划项目(BK2012074)

摘　　要：背景:次级淋巴组织趋化因子(SLC)参与淋巴归巢和抗肿瘤免疫应答,对肠道淋巴细胞有趋化作用。多项动物实验表明SLC参与了溃疡性结肠炎(UC)的发生、发展。目的:探讨SLC在UC患者中的表达及其意义。方法:纳入2010年12月-2012年12月南通大学附属医院40例活动期UC患者,以20名健康志愿者作为正常对照,采用免疫组化法检测结肠组织SLC表达,并分析其与UC病情程度的关系。结果:UC组SLC均阳性表达,正常对照组呈阴性或弱阳性表达,UC组SLC表达显著高于正常对照组,差异有统计学意义(4.16±0.78对0.52±0.11,P<0.05)。UC病变程度越重,SLC表达阳性率越高。结论:SLC参与了UC的发生和发展,其可能在UC局部结肠组织破坏和病理变化中起重要作用。Secondary lymphoid tissue chemokine （SLC） is involved in lymphoid homing and anti-tumor immune response, and has a chemotactic effect on intestinal lymphocytes. Several animal studies have shown that SLC is involved in the occurrence and development of ulcerative colitis （UC）. Aims： To investigate the expression and significance of SLC in UC. Methods： Forty active UC patients from Dec. 2010 to Dec. 2012 at Affiliated Hospital of Nantong University were enrolled, and 20 healthy volunteers were served as controls. Expression of SLC in the colon mucosa was detected by immunohistochemistry, and its relationship with severity of UC was analyzed. Results： SLC was positively expressed in all UC patients, while was negatively or weakly positively expressed in controls. Expression of SLC in UC patients was significantly higher than that in controls （4.16 ±0.78 vs. 0. 52 ±0.11, P 〈0.05）. Expression of SLC was correlated with the severity of involvement of UC. Conclusions： Expression of SLC participates in development and progress of UC. SLC may play an important role in the induction of local damage and pathological changes of UC.

关 键 词：结肠炎 溃疡性 次级淋巴组织趋化因子 免疫组织化学 

分 类 号：R574.62[医药卫生—消化系统]