γ-氨基丁酸B受体与应激性防御反应研究现状  

Progress of gamma-aminobutyric acid B receptor and stress induced defensive reaction

作　　者：袁莲芳[1] 陈果[2] 侯丽[1] 刘利萍[1] 贾宏阁[3] 师建国[2] 

机构地区：[1]西安医学院第二附属医院门诊部,西安710038 [2]第四军医大学病理与病理生理学教研室,西安710032 [3]第四军医大学西京医院神经内科,西安710032

出　　处：《中华实用诊断与治疗杂志》2015年第6期521-523,共3页Journal of Chinese Practical Diagnosis and Therapy

基　　金：陕西省科技厅科学研究项目(2012K15-02-10);陕西省教育厅科学研究项目(12JK0719);西安医学院校级科研计划项目(10FC011)

摘　　要：γ-氨基丁酸(gamma-aminobutyric acid,GABA)是中枢神经系统中主要的抑制性神经递质,通过与GABA受体结合发挥重要生物学功能,目前对GABA受体的研究是神经科学的研究热点之一。GABA受体主要有GABAA、GABAB和GABAC 3类,GABAB受体为代谢型受体,介导缓慢、持续较长的抑制性效应,在脑内参与较多重要生理活动和病理变化。本文对近年有关GABAB受体的研究现状,包括GABAB受体的结构、作用机制、表达、分布、生理作用以及与应激性防御反应的关系等作一综述。Gamma-aminobutyric acid（GABA）is the most important inhibitor neurotransmitter in the central nervous system,showing its biological role by binding with GABA receptor.The research on GABA receptors is the hotspot in neuronscience.GABA receptor is divided into three categories,as GABAA,GABAB and GABAC receptors.GABAB receptor belongs to metabotropic receptors with slow mediation and long-time inhibiting functions.GABAB receptor is involved in different physiological functions and pharmacological changes in the central nervous system.This paper reviews the progression of GABAB receptor in recent years,including molecular structure,the mechanism of action,expression,distribution,physiological function and relevant stress induced defensive reaction.

关 键 词：Γ-氨基丁酸B受体 生理作用 防御反应 

分 类 号：R741[医药卫生—神经病学与精神病学]