吲哚菁绿荧光导航技术在乳腺癌前哨淋巴结活检中的应用  

Application of indocyanine green fluorescence navigation in sentinel lymph node biopsy for breast cancer

作　　者：郭文斌[1] 高伟[1] 刘金涛[1] 葛述科[1] 孔辉[1] 孙琳琳[1] 郭嘉嘉[2] 王殊[2] 

机构地区：[1]辽宁省大连市中心医院乳腺科,辽宁大连116033 [2]北京大学人民医院乳腺中心,北京100044

出　　处：《中国普通外科杂志》2015年第5期658-662,共5页China Journal of General Surgery

摘　　要：目的:评价吲哚菁绿(ICG)荧光技术应用于乳腺癌前哨淋巴结活检(SLNB)的可行性。方法:选择2010年11月—2012年2月期间68例乳腺癌患者,其中36例以ICG荧光导航技术进行SLNB(ICG组),32例应用美蓝为示踪剂行SLNB(染料组)。所有患者SLNB结束后行I、II水平腋窝淋巴清扫。结果:两组基本临床资料差异无统计学意义(均P>0.05),具有可比性。ICG组前哨淋巴结(SLN)检出率为97.2%(35/36),染料组为81.3%(26/32),前者明显高于后者(P<0.05)。假阴性率与每例患者平均检测SLN数量两组间差异无统计学意义(均P>0.05)。结论:用ICG荧光导航技术行乳腺癌SLNB,其检出率高于染料法,且同时具备核素、染料示踪剂的替代选择。Objective：To evaluate the feasibility of using indocyanine green（ICG） fluorescence technique in sentinel lymph node biopsy（SLNB） for breast cancer.Methods：Sixty-eight breast cancer patients admitted between November 2010 and February 2012 were selected.Of the patients,36 cases underwent SLNB with ICG l uorescence navigation（ICG group）,while 32 cases underwent SLNB using methylene blue as a tracer（dye group）.All patients received level I and II axillary dissection after the SLNB.Results：The baseline clinical data between the two groups had no statistical difference（all P0.05）,and were comparable.The detection rate of sentinel lymph nodes（SLNs） was 97.2%（35/36） in ICG group and 81.3%（26/32） in dye group,and the former was significantly higher than the latter（P0.05）.There was no significant difference in false-negative rate and mean number of excised SLNs between the two groups（both P0.05）.Conclusion：The detection rate of using ICG fluorescence navigation SLNB for breast cancer is higher than that of dye tracer,and it can be used as an alternative option for radioactive or dye tracer.

关 键 词：乳腺肿瘤 前哨淋巴结活组织检查 前哨淋巴结活检 荧光染料 

分 类 号：R737.9[医药卫生—肿瘤]