常规处理方案联合铜绿假单胞菌制剂治疗乳腺癌疗效的Meta分析  

Efficacy of conventional therapy combined with use of pseudomonas aeruginosa preparation for treatment of breast cancer:a Meta-analysis

作　　者：郭智慧[1] 罗道蕴[2] 周庆[1] 杨志明[2] 

机构地区：[1]成都医学院第一附属医院甲乳外科,四川成都610500 [2]成都医学院第一附属医院肝胆外科,四川成都610500

出　　处：《中国普通外科杂志》2015年第5期669-676,共8页China Journal of General Surgery

摘　　要：目的:系统性评价铜绿假单胞菌制剂应用于乳腺癌治疗中的效果。方法:检索国内外数据库,检索时间为各数据库建库至2014年11月。纳入在乳腺癌治疗中应用铜绿假单胞菌制剂的随机对照试验(RCT),筛选文献、提取数据和文献质量评价后,用Rev Man 5.1.2软件进行Meta分析。结果:共纳入9篇RCT研究,Meta分析结果显示,常规处理方案联合铜绿假单胞菌制剂明显升高患者完全缓解率(OR=2.22)、总有效率(OR=6.73)、患者Karnofsky评分(MD=9.79)及IL-2水平(SMD=1.56),明显降低患者疾病稳定率(OR=0.36)、疾病进展率(OR=0.18)以及缩短患者术后积液消失时间(MD=-7.52)。结论:联合铜绿假单胞菌制剂可明显提高乳腺癌患者放化疗效果,但该结论仍需要高质量的研究进一步证实。Objective：To systematically evaluate the eifcacy of use of pseudomonas aeruginosa（PA） preparation in treatment of breast cancer.Methods：The randomized controlled trials（RCTs） concerning the use of PA preparation in treatment of breast cancer were collected by searching the national and international databases,and the time period of search ranged from inception of each database until November 2014.After literature screening,data extraction and quality assessment,Meta-analysis was performed by Revman 5.1.2 software.Results：Nine RCTs were ifnally included.The results of Meta-analysis showed that combined use of PApreparation with conventional treatment signiifcantly increased the complete response rate（OR=2.22）,total response rate（OR=6.73）,Karnofsky score（MD=9.79） and IL-2 level,and signiifcantly decreased the stable disease rate（OR=0.36） and progress disease rate（OR=0.18）,as well as shortened the time to disappearance of the postoperative l uid collection（MD=–7.52）.Conclusion：Combined use of PA preparation can increase the efficacy of conventional chemoradiotherapy in treatment of breast cancer,but this conclusion needs further verification by more high quality studies.

关 键 词：乳腺肿瘤 铜绿假单胞菌 随机对照试验 META分析 

分 类 号：R737.9[医药卫生—肿瘤]