晚期恶性肿瘤患者血清肿瘤相关物质的检测与临床应用  

Detection and application of Bo xin serum tumor associated material( BXTM) in advanced malignant tumor patients

作　　者：朱美琴 申维玺 夏俊贤 田忠凯 陈亦欣 叶建增 

机构地区：[1]暨南大学第二临床医学院深圳市人民医院肿瘤内科,广东深圳518020

出　　处：《现代肿瘤医学》2015年第13期1902-1905,共4页Journal of Modern Oncology

摘　　要：目的:探讨晚期恶性肿瘤患者血清肿瘤相关物质(BXTM)含量检测及临床价值。方法:检测250例有复发转移的晚期恶性肿瘤患者、60例无复发转移患者和60例健康体检者血清BXTM含量。结果:晚期恶性肿瘤组BXTM均值为(112.10±20.20)U/ml,阳性率为72.8%。无复发转移患者BXTM均值为(92.35±12.25)U/ml,阳性率为25.0%。正常对照者BXTM均值为(91.28±9.35)U/ml,阳性率为16.7%。复发转移患者血清BXTM含量明显高于无复发转移患者及正常对照者(P<0.05)。无复发转移患者和正常对照者血清BXTM含量无差异(P>0.05)。治疗有效或稳定的患者化疗前血清BXTM含量及其阳性率均低于疾病进展的患者(P<0.05)。结论:血清BXTM检测具有较高的敏感性、特异性和广谱性,临床上可用作晚期恶性肿瘤诊断、疗效判断以及随访检测的参考指标。Objective：To investigate the value of the Bo xin serum tumor associated material（ BXTM）in the diag-nosis of advanced malignant tumors. Methods：With the method of chemical colorimetry,the level of BXTM was deter-mined and comPared in 250 cases with advanced malignant tumor,60 cases with early malignant tumor and 60 Physi-cal examination volunteers. Results：The mean value of BXTM in advanced malignant tumor Patients was（112. 10 ± 20. 20）U/ml,and the sensitive rate was 72. 8%. The mean value of BXTM in early malignant tumor Patients was （92. 35 ± 12. 25）U/ml,and the sensitive rate was 25. 0%. The mean value of BXTM in normal PeoPle was（91. 28 ± 9. 35）U/ml,and the sensitive rate was 16. 7%. The levels of BXTM in serum of advanced malignant tumor Patients were significantly higher than those of early malignant tumor Patients and normal PeoPle（P0. 05）. The levels of BXTM in Patients that achieved PR or SD were less than that had PD（P〈0. 05）. Conclusion：Detecting BXTM in advanced malignant tumor Patients has a higher sensitivity,sPecificity,and wide sPectrum. It can be used as the indi-cator for the diagnosis,treatment effect and follow uP in advanced malignant tumors.

关 键 词：晚期恶性肿瘤 血清肿瘤相关物质 检测 

分 类 号：R730.4[医药卫生—肿瘤]