12例孤立性纤维性肿瘤临床病理分析  

Clinicopathologic analysis of 12 cases of solitary fibrous tumor

作　　者：马丽梅[1] 曾林华[1] 

机构地区：[1]自贡市第三人民医院病理科,四川自贡643020

出　　处：《现代肿瘤医学》2015年第13期1908-1910,共3页Journal of Modern Oncology

摘　　要：目的:探讨孤立性纤维性肿瘤(solitary fibrous tumor,SFT)的临床病理特点、免疫表型、鉴别诊断、生物学行为及预后。方法:收集12例孤立性纤维性肿瘤的临床病理资料和免疫组化染色,并结合文献进行分析讨论。结果:12例孤立性纤维性肿瘤平均发病年龄为40.2(29-70)岁,多发生于胸腔、腹腔,其中1例为恶性SFT。镜下肿瘤细胞多为梭形细胞,少细胞区和多细胞区相间,两者间隔以瘢痕样透明变性粗胶原纤,可见分枝状的血管外皮瘤样区。免疫表型:梭形细胞Vimentin、CD34和CD99弥漫强阳性,不同程度表达Bcl-2、SMA、EMA、Desmin、S-100。结论:SFT属于中间生物学行为的肿瘤,可复发或转移。少数SFT虽然具有实体富于细胞纤维肉瘤样模式,但其生物学行为仍然相对良性。一些组织学良性的SFT在术后10年也可复发和转移,"去分化SFT"预后差。Objective：To analyze the clinical and Pathological features,immunoPhenotyPe and differential diagno-sis,biological behavior and Prognosis of the solitary fibrous tumor（ SFT）. Methods：To collect the solitary fibrous tumor clinicoPathologic materials and immunohistochemical staining information of 12 cases with litaerature review. Results：The average age of Patients with solitary fibrous tumor in the 12 cases was 40. 2（29-70）,it mostly occued in the thoracic cavity,1 case was malignant SFT. Under the microscoPe,the tumor cells were mostly sPindle shaPed cells,with the interPhase of less-cell area and multicellular area,the interval was the thick collagen fiber of scar-a-like hyaline degeneration,the branch-shaPed hemangioPericytoma region was visible. Immune PhenotyPe：The sPindle cell Vimentin,CD34 and CD99 diffuse with strong Positive,showing Bcl-2,SMA,EMA,Desmin,S-100 at different levels. Conclusion：SFT belongs to the tumor with the middle biological behavior,it can relaPse or metastasis. Al-though a minority of SFT has the Pattern of the solid cellular fibrosarcoma,itˊs biological behavior is still a relatively benign . Some histological benign SFT may have recurrence and metastasis 10 years after the oPeration,the Prognosis of〝differentiation of SFT〝 is Poor.

关 键 词：孤立性纤维性肿瘤 免疫组化 鉴别诊断 预后 

分 类 号：R738.3[医药卫生—肿瘤]