彩色多普勒超声在儿童神经母细胞瘤化疗监测方面的应用价值  

The value of color doppler ultrasound in pediatric neuroblastoma during chemotherapy

作　　者：史鹏丽[1] 国兰兰[1] 马灵芝[1] 

机构地区：[1]中国医科大学附属第四医院超声科,辽宁沈阳110032

出　　处：《现代肿瘤医学》2015年第14期2044-2046,共3页Journal of Modern Oncology

摘　　要：目的:评价彩色多普勒超声检查在儿童神经母细胞瘤化疗监测方面的临床价值。方法:收集27例经病理证实的腹部神经母细胞瘤患儿资料,分为手术组19例和非手术组8例,所有患儿于化疗前、后均行彩色多普勒超声检查,随访观察2-48个月,对比化疗前后的超声图像变化。结果:手术组19例患儿中,彩色多普勒超声显示肿瘤复发4例、手术后残留3例。定期化疗后4例(21.1%)病情好转,8例(42.1%)病情稳定,7例(36.8%)病情恶化;非手术组8例患儿中,彩色多普勒超声显示5例瘤体体积缩小,4例瘤体内钙化明显增多、密集分布,6例瘤体内血流减少,定期化疗后6例(75%)病情缓解,2例(25%)病情恶化。结论:彩色多普勒超声检查具有无电离辐射、可重复检查等特点,能清晰对比神经母细胞瘤化疗前后原发病灶、腹部器官转移及大血管等情况的变化,是儿童神经母细胞瘤化疗监测的重要检查方法。Objective：To evaluate the clinical value of color doppler ultrasound in pediatric neuroblastoma during chemotherapy.Methods：The data of 27 cases with pediatric abdominal neuroblastoma confirmed by pathology were collected,which were divided into two groups：operation group（19 cases） and non operation group （8 cases）.All patients were received color doppler ultrasound before and after chemotherapy,and the changes of ultrasonic images were compared.Results：Among the 19 cases in operation group,color doppler ultrasound showed 4 cases had tumor recurrence and 3 cases had postoperative residual,with patient＇s condition of 4 （21.1％）cases improved,8 （42.1％）cases stable,and 7（36.8％）worse after regular chemotherapy.Among the 8 cases in non operation group,color doppler ultrasound showed the volumes of 5 tumors were diminished,and the calcifications in 4 tumors were increased significantly and close-set,and the blood flow of 6 tumors was reduced,with patient＇s condition of 6 （75％）cases relieved and 2（25％）cases worse after regular chemotherapy.Conclusion：With the features of no ionizing radiation and repeated checking,color doppler ultrasound can compare clearly the changes of primary tumor and abdominal organ metastasis and great vessels before and after chemotherapy,and it is a significant inspection method of chemotherapy monitoring of pediatric neuroblastoma.

关 键 词：儿童 神经母细胞瘤 彩色多普勒超声检查 化疗 

分 类 号：R739.4[医药卫生—肿瘤]