聚集素的结构特点与功能及其在肝细胞癌诊疗中的作用  

Structural features and function of clusterin and its role in progression of hepatocellular carcinoma

作　　者：钱琦[1] 郑文杰[1] 姚登福[1] 

机构地区：[1]南通大学附属医院临床医学研究中心,江苏南通226001

出　　处：《临床肝胆病杂志》2015年第5期810-812,共3页Journal of Clinical Hepatology

基　　金：国家国际科技合作专项(2013DFA32150);江苏省临床医学科技专项(BL2012053);南通市社会事业科技创新与示范(HS2014007)

摘　　要：肝细胞癌(HCC)是我国常见的恶性肿瘤之一,其发生、发展机制十分复杂。聚集素(CLU)被证实对HCC的发生、发展起重要作用。综述了CLU的分子结构特点和生物学功能及其对HCC的诊断价值,分析了化疗多药耐药联系和未来靶向治疗前景。认为CLU有望作为HCC新的分子标志物及靶向治疗位点。Hepatocellular carcinoma （HCC）is one of the most common malignant tumors in China,with a very complex mechanism of de-velopment and progression.Clusterin （CLU）has been confirmed to play an important role in the development and progression of HCC.This paper reviews the molecular structure and biological function of CLU and its value for early diagnosis of HCC and analyzes its association with multi -drug resistance in chemotherapy and the prospect of targeted therapy.CLU holds promise as a new molecular marker of HCC and the therapeutic target.

关 键 词：肝肿瘤 聚集素 多药耐药相关蛋白质类 基因表达调控 综述 

分 类 号：R735.7[医药卫生—肿瘤]