一株水貂阿留申病毒VP2基因的高变区测序分析  

Sequencing Analyses of the Hypervariable Region within the VP2 Gene of a Strain of the Aleutian Mink Disease Virus

作　　者：张蕾[1] 胡博[1] 白雪[1] 张海玲[1] 赵建军[1] 王振军[1] 马凡舒 闫喜军[1] 吴威[1] 徐淑娟[1] 

机构地区：[1]中国农业科学院特产研究所,吉林省特种动物分子生物学省部共建国家重点实验室,长春130122

出　　处：《病毒学报》2015年第3期226-230,共5页Chinese Journal of Virology

基　　金：吉林省科技发展计划项目任务书201201001;吉林省科技攻关计划:20140204074NY

摘　　要：为分析我国水貂阿留申病(Aleutian disease,AD)跨宿主传播的分子机制,扩增获得一株吉林地区水貂阿留申病毒(Aleutian disease virus,ADV)VP2基因高变区片段。序列分析表明,第235位存在与参考毒株不同的氨基酸位点,进化树分析结果表明,该毒株与丹麦高致病毒株ADV-K亲缘关系较近。ADV第235位氨基酸位点可能与病毒的感染能力相关。To analyze the molecular mechanisms of cross-host transmission of the Aleutian mink disease virus（ADV）,the hypervariable region fragment of the VP2 gene of the ADV in Jilin Province（China）was amplified.Sequencing analyses showed diversity at residue 174 by comparison with other VP2 genes in GenBank.The phylogenetic tree indicated that the ADV-JL strain had a close relationship with the highly pathogenic strain from Denmark：ADV-K.Results implied that residue 174 may be associated with ADV infectivity.

关 键 词：水貂阿留申病毒 VP2高变区 跨宿主传播 

分 类 号：S852.65[农业科学—基础兽医学]