线粒体DNA突变与衰老关系的研究进展  

Progress in the Relation of MitochondrialDNA and Aging

作　　者：李福记 陈凤平[1] 吕宇[1] 吴华裕[1] 

机构地区：[1]广西医科大学基础医学院细胞生物学与遗传学教研室,广西南宁530021

出　　处：《生物技术通讯》2015年第3期430-432,共3页Letters in Biotechnology

基　　金：国家自然科学基金(81260479);广西自然科学青年基金(2013GXNSFBA019143);广西高校大学生创新创业训练计划(201410598030)

摘　　要：衰老的分子机制复杂,目前的研究尚未能对衰老的关键轴心获得一致而明晰的理论认识,各种衰老假说相继被提出,其中具有代表性的为端粒学说。端粒-p53-线粒体衰老轴线自从被提出,已经获得越来越多的实验论证,较多的研究也表明线粒体DNA突变与衰老有着密切的相关性,但突变与衰老之间的因果关系存在较大争议。我们简要综述了近年来线粒体DNA突变与衰老关系的相关研究进展。The molecular mechanisms of aging is complex and mysterious,current studies does not obtain theconsistent understanding of key axis on the aging.Various aging hypothesis have been proposed,which is represen-tative of the telomere theory.Since the telomere-p53-mitochondrial aging axis has being proposed,more and morestudies have shown that mitochondrialDNA mutations are closely associated with aging,but more controversialcausal relationship between senescence and mutation is in discussion.In this paper we reviewed the progress ofmitochondrialDNA mutation associated with aging in recent years.

关 键 词：端粒 线粒体DNA 突变 衰老 

分 类 号：Q25[生物学—细胞生物学]