组织因子对急性早幼粒细胞白血病凝血功能紊乱发生的影响  

Study on the Effect of Tissue Factor in the Coagulopathy of Acute Promyelocytic Leukemia

作　　者：兰文家 史策[1] 周晋[1] 

机构地区：[1]哈尔滨医科大学附属第一医院血液内科,哈尔滨150001

出　　处：《医学综述》2015年第12期2139-2142,共4页Medical Recapitulate

摘　　要：出血和血栓并发症是导致急性早幼粒细胞白血病(APL)患者死亡的主要因素。在出血及凝血功能紊乱发生、发展中,组织因子(TF)的高表达可以造成患者血液高凝,进一步促进凝血紊乱的发生。TF的高表达与早幼粒细胞白血病/维甲酸受体、细胞因子和细胞膜表面磷脂酰丝氨酸暴露密切相关。作为凝血活化的交汇点,选择性抑制TF对改善APL出凝血紊乱和弥散性血管内凝血发生极为重要。Hemorrhage and thrombotic complications are the major causes for mortality in patients with acute promyelocytic leukemia（ APL）. During the incidence and development of hemorrhage and coagulopathy,highly expressed tissue factor（ TF） can initiate the hypercoagulability and lead to coagulopathy and fatal hemorrhage. The high expression of TF is closely related with promyelocytic leukemia / retinoic acid receptorα,cytokines and phosphatidylserine exposure in membrane surfaces. Selective inhibition of TF,the intersection of coagulation activation,plays an important role in improving APL hemostatic dysfunction and disseminated intravascular coagulation.

关 键 词：急性早幼粒细胞白血病 组织因子 凝血功能紊乱 弥散性血管内凝血 

分 类 号：R733.71[医药卫生—肿瘤]