EMT与骨肉瘤转移相关性的研究进展  

Relationship between EMT and Metastasis of Osteosarcoma

作　　者：种阳[1] 李国军[1] 张世谦[1] 邵明[1] 杨艳梅[2] 

机构地区：[1]哈尔滨医科大学附属第一医院骨科,哈尔滨150001 [2]哈尔滨医科大学肿瘤防治研究所,哈尔滨150001

出　　处：《医学综述》2015年第12期2185-2188,共4页Medical Recapitulate

摘　　要：上皮-间质转化(EMT)是指上皮细胞转化为间充质细胞的过程,EMT可增强肿瘤细胞的侵袭和转移能力。既往研究发现,EMT可以通过影响多种基因及通路来影响多种肿瘤的侵袭和转移,除此之外,EMT也会与细胞周期中的某些酶具有一定的相关性。骨肉瘤细胞作为骨肿瘤中转移性较强的一种,其转移性与EMT的关系尚未明确。该文旨在阐明EMT与骨肉瘤细胞转移性的相互关系,希望可以为抑制骨肉瘤转移提供新的思路。Epithelial-mesenchymal transiton（ EMT） is a procedure of epithelial cells turning into mesenchymal cells. EMT can enhance the invasive and metastatic abilities of cancer cells. Previous studies showed us that EMT can influence many genes and paths to influence the invasion and metastasis of tumors.Besides,EMT is also associated with some enzymes of cell cycle. Osteosarcoma is one of the bone tumors with strong metastasis. The relationship between EMT and osteosarcoma＇ s metastasis is little known so far. Here focuses on the correlation between EMT and osteosarcoma＇s meatstasis,with the hope to provide new ideas to inhibit the metastasis of osteosacoma.

关 键 词：骨肉瘤 上皮-间质转化 转移 

分 类 号：R738.1[医药卫生—肿瘤]