预测肝癌术后早期与晚期的复发因素研究  

Predictive factors of early and late recurrence in patients with hepatocellular carcinoma

作　　者：陈柯[1,2] 田云鸿[1,2] 刘小红[1,2] 

机构地区：[1]川北医学院第二临床医学院 [2]南充市中心医院肝胆外科,四川南充637000

出　　处：《西部医学》2015年第7期1008-1010,共3页Medical Journal of West China

基　　金：四川省教育厅科研课题(12ZB042)

摘　　要：目的探讨预测肝癌患者术后早期与晚期的复发因素。方法回顾性分析106例肝癌根治性切除患者的临床病理特征。应用单因素及多因素分析预测患者术后复发的危险因素。结果单因素分析提示:年龄大于60岁、肿瘤分型、微血管侵犯和AFP是预测患者术后早期复发(<2年)的主要因素;Child分级、肝硬化、AFP是预测术后晚期复发(>5年)的危险因素;多因素分析提示:肿瘤分型、微血管侵犯是预测肝癌患者术后早期复发的独立因素,肝硬化是预测术后晚期复发的独立危险因素。结论肿瘤分型和微血管侵犯可预测肝癌术后早期复发,肝硬化可预测肝癌术后晚期复发。Objective To identify preoperative predictors of early and late recurrence in patients with hepatocellular carcinoma（HCC）.Methods 106 patients underwent curative hepatic resection for HCC were included.The preoperative predictors of recurrence were analyzed with Univariate and multivariate analysis.Results By univariate analysis,age〉60years,the type of tumor,microvascular invasion and AFP were statistically significantly associated with early recurrence（less than 2years）.Child grade,liver cirrhosis and AFP were statistically significantly associated with late recurrence（more than 5years）in patients with HCC.By multivariate analysis,the type of tumor and microvascular invasion were independent predictive factors in identifying early recurrence.Liver cirrhosis was independent predictive factors in identifying late recurrence in patients with HCC.Conclusion The type of tumor and microvascular invasion are important elements in identifying early recurrence in patients with HCC.Liver cirrhosis is important elements in identifying late recurrence in patients with HCC.

关 键 词：肝癌 手术 复发 

分 类 号：R735.7[医药卫生—肿瘤]