磺酰脲类除草剂咪唑磺隆及其衍生物的合成  

Synthesis of Sulfonylurea Herbicides Imazosulfuron and Its Derivatives

作　　者：石桂珍[1] 葛军营[1] 窦建芝[1] 张在珍[1] 

机构地区：[1]潍坊工程职业学院,山东青州262500

出　　处：《煤炭与化工》2015年第6期43-45,139,共4页Coal and Chemical Industry

摘　　要：以2-氨基吡啶和氯磺酸为原料,首先经氯磺化和氨解反应合成了中间体2-氯咪唑并[1,2-a]吡啶-3-磺酰胺,接着采用胍与β-二羰基化合物缩合合成了5种4,6-位取代和4,5,6-位取代的2-氨基嘧啶化合物,然后磺酰胺与氯甲酸苯酯反应生成磺酰基氨基甲酸苯酯,最后再与2-氨基嘧啶化合物发生加成反应来制备咪唑磺隆及其衍生物(化合物1-5)。采用熔点测定、FTIR、MS和1H NMR等手段分析和确认目标产物的结构。Taking 2- aminopyridine and chlorosulfonic acid as raw material, the intermediate 2- chloroimidazo [1,2- a]pyridine- 3- sulfonamide was first synthesized through the reaction of chlorosulfonation and ammonolysis. Then, five kinds of 4,6- substituted and 4,5,6- substituted 2- aminopyrimidine compounds were synthesized through condensation reaction of carbamidine and β- dicarbonyl compounds. Next, sulfonyl carbamic acid benzyl ester was obtained through the reaction of sulfonamide and phenyl chloroformate. At last, through addition reaction of the resulting compound with 2- amino pyrimidine compounds imazosulfuron and its derivates（ compounds 1- 5） were obtained. The structure of the target products were analyzed and affirmed by melting point, Fourier transform infrared spectra, mass spectra, hydrogen spectra of nuclear magnetic resonance and other methods.

关 键 词：咪唑磺隆 衍生物 合成 

分 类 号：TQ457.2[化学工程—农药化工]