姜黄素对胰腺癌细胞PANC-1体外侵袭转移的影响  

Effects of Curcumin on Invasion and Metastasis of Human Pancreatic Can cer Cells PANC-1

作　　者：陈龙佩 吴杰[1] 孟颖[1] 陶敏[1] 

机构地区：[1]苏州大学附属第一医院肿瘤科,江苏苏州215006

出　　处：《现代仪器与医疗》2015年第4期1-3,共3页Modern Instruments & Medical Treatment

基　　金：国家自然科学基金(81272542);江苏省卫生厅医学科研项目(Z201206)

摘　　要：目的 :探讨姜黄素对胰腺癌PANC-1细胞侵袭转移的影响。方法 :以10μmol/m L、20μmol/m L、30μmol/m L和60μmol/m L姜黄素处理胰腺癌PANC-1细胞,MTT法检测其对PANC-1细胞的生长和抑制作用。应用Transwell小室进行人工重组基底膜(Matrigel)侵袭和运动实验,观察姜黄素对PANC-1细胞侵袭和转移的影响。结果 :应用姜黄素处理后胰腺癌细胞生长受到抑制且作用呈时效、量效依赖关系;非致死浓度姜黄素处理后胰腺癌PANC-1细胞侵袭和转移明显降低。结论:姜黄素能够减弱胰腺癌细胞PANC-1的侵袭和转移。Objective： To explore the effects ofcurcumin on invasion and metastasis of the human pancreatic cancer cells PANC-1. Method： PANC-1 were treated with 10, 20,30 and 60μmol/ml curcumin,respectively. Proliferation of PANC-1 cells was measured with MTT assay. Invasion and metastasis of PANC-1 cells were evaluated with Transwell chamber. Result： After being treated with curcumin, the proliferation of Pancreatic cells was inhibited in a time and dose-depending manner. The invasion and metastasis of Pancreatic cells were also inhibited. Conclusion： Curcumin could restrain the invasion and metastasis of the human pancreatic cancer cells PANC- 1.

关 键 词：胰腺癌 姜黄素 侵袭 转移 

分 类 号：R735.9[医药卫生—肿瘤]