射频消融联合经导管动脉化疗栓塞在原发性肝癌中的应用  

Application of Radiofrequency Ablation Combined with Transcatheter Arterial Chemoembolization in Primary Hepatocellular Carcinoma

作　　者：李权 

机构地区：[1]湖北省中西医结合医院肿瘤科,湖北武汉430015

出　　处：《武汉大学学报（医学版）》2015年第4期571-574,共4页Medical Journal of Wuhan University

摘　　要：目的:探讨射频消融(RFA)联合经导管动脉化疗栓塞(TACE)治疗原发性肝癌的临床效果。方法:将我院2008年2月至2011年3月期间收治的88例原发性肝癌患者随机分为实验组44例和对照组44例,两组患者均先进行3-4次TACE治疗,每次治疗间隔4-6周,实验组患者在TACE治疗后2周开始进行1-2次RFA治疗,每次治疗间隔2-3周,治疗后对比观察两组患者的近期疗效、生存率和不良反应发生率。结果:实验组患者在经过联合治疗后的近期疗效有效率(75.0%)显著高于对照组患者(52.3%),差异具有统计学意义(χ2=5.317;P<0.05);并且实验组患者的1、2、3年及以上的生存率分别为88.6%、59.1%、47.7%,而对照组为41.0%、18.2%、6.8%,实验组明显优于对照组,差异具有统计学意义(P<0.05);而两组患者的不良反应发生率比较差异无统计学意义(P>0.05)。结论:TACE与RFA联合法在原发性肝癌患者的治疗中有较好的近期效果,并且可以有效控制肿瘤的局部生长,延长生存期。Objective： To investigate the clinical effect of Radiofrequency Ablation （RFA） combined with Transcatheter Arterial Chemoembolization （TACE） in the treatment of primary liver canc- er. Methods： 88 patients with primary liver cancer were admitted in our hospital during the period from 2008 February to 2011 March and randomly divided into experimental group and control group with 44 cases in each group. First, two groups of patients were given 3-4 TACE treat- ment, and each treatment interval was 4-6 weeks. Patients in the experimental group were treated with 1-2 RFA treatment after 2 weeks of the treatment of TACE. After the treatment, the recent curative effect, survival rate and the incidence of adverse reaction were observed and compared between the two groups. Results： After treatment, the short term curative effect of RR in experi- ment group （75%） was significantly higher than that of the control group （52. 3%）, and the difference was statistically significant（X^2 =5. 317; P〈0.05）; The 1 year survival rate, survival rate of 2 years, 3 years and 3 years above in experimental group were 88.6%, 59.1%, 47.7% re- spectively, while they were 41. 0%, 18. 2%, 6. 8% in the control group, which showd bettereffect in the experimental group than in the control group, and the difference was statistically sig- nificant （P〈0.05）. There was no significant difference in adverse reactions between the two groups （P〉0.05）. Conclusion： TACE and RFA combined method has a good short-term effect in the treatment of primary liver cancer, and can effectively control the local growth of tumor, and prolong the survival time of patients.

关 键 词：原发性肝癌 经导管动脉化疗栓塞 射频消融法 

分 类 号：R735.7[医药卫生—肿瘤]