^(18)F-FDG PET/CT显像与VEGF表达对肺癌预后的诊断价值  

^(18)F-FDG PET/CT imaging and VEGF expression in diagnosis of lung cancer prognosis

作　　者：周晓亮[1] 邓豪余[2] 李新辉[2] 吴武林[1] 娄明武[1] 莫逸[3] 谢爱民[3] 

机构地区：[1]广东省深圳市龙岗中心医院影像科,广东深圳518116 [2]中南大学湘雅医院核医学科,湖南长沙410008 [3]湖南省肿瘤医院PET/CT中心,湖南长沙410013

出　　处：《医学影像学杂志》2015年第5期811-814,共4页Journal of Medical Imaging

摘　　要：目的分析非小细胞肺癌组织VEGF表达与18 F-FDG摄取之间的关系。探讨研究肿块SUV、VEGF表达在评价肺癌术后复发中的价值。方法 40例非小细胞肺癌患者(腺癌14例、鳞癌20例、腺鳞癌6例),均行全身PET/CT显像检查测量肿块平均SUV,取术后肿块组织作VEGF免疫组化检测。采用Mattern半定量分析方法对肿块组织VEGF表达进行总评分。对非小细胞肺癌组织VEGF表达评分与SUV相关性进行统计学分析。结果 40例非小细胞肺癌组织VEGF表达与SUV显著相关,VEGF评分越高,SUV越高,r=0.478,P<0.01。术后随访病例中半年内复发组复发组肿块组织平均SUV(6.78±2.62)明显高于未复发组(3.85±1.33),VEGF评分(4.51±1.45)也明显高于未复发组(2.48±1.71),P值均<0.05。结论非小细胞肺癌组织中VEGF表达越高,其术后发生复发和/或转移的可能性越大。VEGF表达评分可考虑作为患者预后和近期复查的参考指标。Objective To analyse the association betweeen 18 F‐FDG absortion and the expression level of VEGF in NSCLC .The value evaluation of SUV and VEGF expression in tumor recurrence after resection of lung cancer were slud‐ied .Methods 40 patients with non small cell lung cancer （20 squamous cell carcinoma ,14 adeno carcinoma and 6 adeno‐squamous carcinoma） underwent whole‐body PET/CT imaging .After taken measurement of mass averaged SUV ,tumor tissue was detected by VEGF immunohistochemistry .By using Mattern semi quantitative analysis method ,tumor tissue VEGF expression for the total score was caulated .In non small cell lung cancer VEGF expression score and SUV were statistically analyzed .Results 40 cases of non small cell lung cancer tissue VEGF expression was significantly correlated with SUV ,the higher VEGF score ,the higher SUV ,r=0 .478 ,P〈0 .01 .Postoperative follow‐up cases within half year relapse group and recurrence group mass organization mean SUV （6 .78 ± 2 .62） was significantly higher than that of the non recurrent group （3 .85 ± 1 .33） ,VEGF scores （4 .51 ± 1 .45） were significantly higher than those in non recurrent group （2.48 ± 1 .71） ,P values were 〈0 .05 .Conclusion VEGF expression of non‐small cell lung cancer is higher ,the postoperative recurrence and /or metastasis is more likely .The expression of VEGF score can be considered as a reference index and prognosis in patients with recent review .

关 键 词：非小细胞肺癌 血管内皮生长因子 标准化摄取值 体层摄影术  X线计算机 

分 类 号：R734.2[医药卫生—肿瘤]