肌层浸润性膀胱癌髂内动脉化疗的临床疗效  

Efficacy of internal iliac artery chemotherapy in muscle-invasive bladder cancer

作　　者：曹敬毅[1] 王淇超[1] 王乾[1] 吴刚[1] 

机构地区：[1]徐州市肿瘤医院泌尿外科,江苏省221005

出　　处：《江苏医药》2015年第11期1267-1269,共3页Jiangsu Medical Journal

基　　金：徐州市科委资助课题(XN13B082)

摘　　要：目的评价肌层浸润性膀胱癌髂内动脉介入化疗疗效。方法回顾性分析肌层浸润性膀胱癌患者行根治性经尿道膀胱肿瘤电切术(TURBT)后联合髂内动脉介入化疗(A组,19例)和单纯行根治性TURBT术(B组,25例)资料,比较髂内动脉化疗前后病理分期的改变,分析5年累计生存率和膀胱保留率的差异。结果与B组相比,A组髂内动脉化疗后病理分期降低至pT0N0期比例高于B组(52.6%vs.12.0%)(P<0.05)。A组患者5年累积生存率高于B组(56.5%vs.44.3%)(P<0.05)。A组膀胱保留率高于B组(78.9%vs.56.0%)(P<0.05)。结论对肌层浸润性膀胱癌患者,TURBT术后联合髂内动脉化疗的疗效优于单纯行根治性TURBT手术。Objective To evaluate the efficacy of internal iliac artery chemotherapy in muscle- invasive bladder cancer. Methods Data of 19 patients with muscle-invasive bladder cancer underwent radical transurethral resection of bladder tumor（TURBT） plus internal lilac artery chemotherapy （group A） and 25 patients with muscle-invasive bladder cancer underwent TURBT alone（group B） were retrospectively analyzed. The changes of pathological stage, 5-year survival rate and bladder preservation rate were compared between two groups. Results The percentage of patients with down- staging to pTON0 pathologically was higher in group A than that in group B（52.6% vs. 12.0%） （P〈0. 05）. The 5-year survival rate was higher in group A than that in group B（56.5〈 vs. 44. 3〈） （P〈0. 05）. The bladder preservation rate was higher in group A than that in group B（78. 9% vs. 56.0〈）（P〈0. 05）. Conclusion In the patients with muscle-invasive bladder cancer, TURBT plus internal lilac artery chemotherapy has better efficacy than TURBT alone.

关 键 词：肌层浸润性膀胱癌 根治性经尿道膀胱肿瘤电切术 髂内动脉化疗 

分 类 号：R737[医药卫生—肿瘤]