前列腺液Gal-3浓度对前列腺癌诊断的临床价值  

Role of Gal-3 concentration in prostatic fluid in the diagnosis of prostate cancer

作　　者：谢赣生[1] 李金虎[1] 黄玉华[1] 严春寅[1] 侯建全[1] 浦金贤[1] 李纲[1] 欧阳骏[1] 

机构地区：[1]苏州大学附属第一医院泌尿外科,江苏省215006

出　　处：《江苏医药》2015年第11期1277-1279,共3页Jiangsu Medical Journal

摘　　要：目的探讨前列腺液半乳凝素3(Gal-3)浓度对诊断前列腺癌的临床价值。方法采用人Gal-3抗体免疫组化法对31例中老年男性前列腺穿刺组织进行染色,并按病理诊断分为前列腺癌组(A组,12例)和前列腺增生组(B组,19例)。应用多克隆抗体ELISA法检测前列腺液Gal-3浓度,分析两组Gal-3的表达差异。结果 A组前列腺液Gal-3浓度3703.3μg/ml,高于B组的1028.4μg/ml(P<0.01);A组前列腺组织Gal-3表达量亦大于B组(P<0.01)。4例前列腺癌患者合并转移性骨损害;其前列腺液Gal-3浓度高于8例非转移前列腺癌患者[(5265.6±345.2)μg/ml vs.(2292.1±1325.4)μg/ml](P<0.05)。取前列腺液Gal-3浓度为4167μg/ml时,其诊断前列腺癌的敏感度为100%,特异度为80%。结论前列腺液Gal-3检测可用于前列腺癌的诊断和是否发生骨转移的评估。Objective To explore the clinical value of the concentration of Gal-3 in prostatic fluid in the diagnosis of prostate cancer（PC）. Methods Transrectal ultrasound-guided prostate biopsy was performed in 31 men suspected with prostate cancer. On the basis of pathological diagnosis, the patients were assigned into two groups of A（diagnosed as PC, 12 cases） and B （diagnosed as benign prostatic hyperplasia, 19 cases）. The concentration of Gal-3 in prostatic fluid was detected by polyclonal antibody ELISA,which was compared between two groups. Results The concentration of Gal-3 in prostatic fluid was higher in group A than that in group B （3703. 3 μg/ml vs. 1028.4 μg/ml） （P〈0. 01）,which in group A was higher in PC patients with bone metastasis（4 cases） than that in those without（8 eases）E（5265.6± 345.2） μg/ml vs. （2292. 1± 1325.4） μg/ml）] （P〈0. 05）. Taking 4167 μg/ml as a cutoff value of Gal-3 in prostatic fluid,the sensitivity and speciality for the diagnosis of PC were 100% and 80%, respectively. The Gal-3 expression in prostate tissues was higher in group A than that in group B（P〈0. 01）. Conclusion The concentration of Gal-3 in prostatic fluid can be taken as a valuable indicator in the diagnosis of PC and evaluation of its metastasis.

关 键 词：半乳凝素3 前列腺癌 良性前列腺增生 

分 类 号：R737[医药卫生—肿瘤]