高血压、2型糖尿病并发牙周炎患者超敏C-反应蛋白及炎性细胞因子表达分析  

The expression of high sensitive C-reactive protein and inflammation cytokines in periodontitis patients with hypertension and type 2 diabetes mellitus

作　　者：施六霞[1] 金岳龙[2] 王祥雨[3] 贺连平[2] 姚应水[2] 

机构地区：[1]皖南医学院口腔医学院 [2]皖南医学院公共卫生学院 [3]淮北朝阳医院口腔科

出　　处：《中国临床药理学与治疗学》2015年第5期541-545,共5页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金(81072367);安徽省自然科学基金(090413126;1308085MH135);安徽高校省级自然科学研究项目(KJ2012B205);安徽省高校优秀青年人才支持计划(2014年安徽省教育厅)

摘　　要：目的:观察高血压、2型糖尿病并发牙周炎患者血清超敏C-反应蛋白(high sensitive C-reactive protein,hs-CRP)、白介素-1β(interleukin 1β,IL-1β)、白介素-6(interleukin 6,IL-6)和肿瘤坏死因子-α(tumor necrosis factors-α,TNF-α)表达情况,探讨高血压、2型糖尿病对牙周炎发生与发展的影响。方法:从某医院体检人群中筛选140名患者(单纯牙周炎组40名、高血压并发牙周炎组35名、2型糖尿病并发牙周炎组40名和2型糖尿病合并高血压并发牙周炎组25名)作为研究对象,记录其牙周探诊深度(probing depth,PD)、附着丧失(attachment loss,AL)、菌斑指数(plaque index,PLI)和出血指数(bleeding index,BI),并检测外周血hs-CRP、IL-1β、IL-6和TNF-α的浓度。结果:2型糖尿病合并高血压并发牙周炎组PD、AL、PLI、BI指标检测结果高于单纯牙周炎组、高血压并发牙周炎组和2型糖尿病并发牙周炎组(P<0.05),高血压并发牙周炎组和2型糖尿病并发牙周炎组高于单纯牙周炎组(P<0.05);2型糖尿病合并高血压并发牙周炎组hs-CRP、IL-1β、IL-6和TNF-α检测结果高于单纯牙周炎组、高血压并发牙周炎组和2型糖尿病并发牙周炎组(P<0.05),高血压并发牙周炎组和2型糖尿病并发牙周炎组高于单纯牙周炎组(P<0.05)。患者血压、血糖水平与hs-CRP、IL-1β、IL-6和TNF-α水平呈正相关(P<0.01)。结论:高血压、2型糖尿病,尤其是高血压合并2型糖尿病并发牙周炎患者血清hs-CRP、IL-1β、IL-6和TNF-α水平较高,提示高血压合并2型糖尿病可能会加重牙周炎症发生与发展的风险。AIM： To observe the levels of serum high sensitive C-reactive protein（ hs-CRP）,interleukin 1β（ IL-1β）, interleukin 6（ IL-6） and tumor necrosis factors-α（ TNF-α） in periodontitis patients with hypertension,type 2 diabetes mellitus and investigate the effect of hypertension,type 2 diabetes on the occurrence and development of periodontitis. METHODS： 140 patients from a hospital physical examination population（40 with only periodontitis,35 with periodontitis and hypertension,40 with periodontitis and type 2 diabetes mellitus,25 with periodontitis and hypertension and type 2 diabetes mellitus） were included in this study. Periodontal examinations,including periodontal probing depth（ PD）, attachment loss（ AL）, plaque index（PLI）,bleeding index（BI） were recorded. The peripheral blood levels of hs-CRP,IL-1β,IL-6 and TNF-α were measured. RESULTS： The levels of PD,AL,PLI,BI in type 2 diabetes mellitus and hypertension complicated with periodontitis group were higher than those in periodontitis group,hypertension with periodontitis group and type 2 diabetes mellitus with periodontitis group（ P〈0. 05）. Those in hypertension complicated with periodontitis group,type 2 diabetes mellitus complicated with periodontitis group were higher than those in simple periodontitis group（ P〈0. 05）. The levels of hs-CRP,IL-1β,IL-6 and TNF-α in type 2 diabetes mellitus and hypertension complicated with periodontitis group were higher than those in periodontitis group,hypertension with periodontitis group and type 2 diabetes mellitus with periodontitis group（ P〈0. 05）. Those in hypertension complicated with periodontitis group and type 2 diabetes mellitus complicated with periodontitis group were higher than simple periodontitis group（ P〈0. 05）. The levels of blood pressure and blood glucose in patients were the positive correlation with the levels of hs-CRP, IL-1β,IL-6 and TNF-α（ P〈0. 01）. CONCLUSION： The levels of hs-CRP,IL-1 beta,IL-6 and TNF-α in periodon

关 键 词：牙周炎 高血压 糖尿病 超敏C-反应蛋白 炎性细胞因子 

分 类 号：R781.4[医药卫生—口腔医学]