基于多层感知器神经网络的双相障碍早期识别研究  

Research on Early Identification of Bipolar Disorder Based on Multi-layer Perceptron Neural Network

作　　者：章浩伟[1] 高燕妮[1] 苑成梅[2] 刘颖[1] 张可[1] 丁宇清[1] 

机构地区：[1]上海理工大学医疗器械与食品学院,上海200093 [2]上海市精神卫生中心心境障碍科,上海200030

出　　处：《生物医学工程学杂志》2015年第3期537-541,共5页Journal of Biomedical Engineering

基　　金：上海市科委医学领先项目资助(12401907700);上海理工大学卓越工程师培养计划;上海理工大学核心课程;上海理工大学第六届微创励志创新基金

摘　　要：多层感知器(MLP)神经网络属于多层前馈神经网络,具有高度智能化的特征与能力,其可以通过网络自身学习来实现复杂的非线性映射。双相障碍是一种严重的精神疾病,具有高复发率、自残率和自杀率。大多数双相障碍以抑郁发作起病,容易被误诊为单相抑郁症而延误治疗,影响预后。双相障碍的早期识别对双相障碍患者非常重要,由于该过程的非线性特点,本文探讨了MLP神经网络应用于双相障碍早期识别的效果。样本数据分为两组,包括复发抑郁组143例及双相障碍组107例;通过对两组间的临床特征进行统计学分析,筛选出具有显著差别的42个变量作为神经网络的输入变量;本研究通过选取不同的神经网络内部结构,随机抽取部分案例作为学习样本,其它作为测试样本,对于双相障碍的识别均获得了较好结果,说明MLP神经网络可应用于双相障碍的早期识别中。Multi-layer perceptron （MLP） neural network belongs to multi-layer feedforward neural network, and has the ability and characteristics of high intelligence. It can realize the complex nonlinear mapping by its own learning through the network. Bipolar disorder is a serious mental illness with high recurrence rate, high self-harm rate and high suicide rate. Most of the onset of the bipolar disorder starts with depressive episode, which can be easily misdi- agnosed as unipolar depression and lead to a delayed treatment so as to influence the prognosis. The early identifica- tion of bipolar disorder is of great importance for patients with bipolar disorder. Due to the fact that the process of early identification of bipolar disorder is nonlinear, we in this paper discuss the MLP neural network application in early identification of bipolar disorder. This study covered 250 cases, including 143 cases with recurrent depression and 107 cases with bipolar disorder, and clinical features were statistically analyzed between the two groups. A total of 42 variables with significant differences were screened as the input variables of the neural network. Part of the samples were randomly selected as the learning sample, and the other as the test sample. By choosing different neural network structures, all results of the identification of bipolar disorder were relatively good, which showed that MLP neural network could be used in the early identification of bipolar disorder.

关 键 词：多层感知器神经网络 双相障碍 早期识别 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R-331[医药卫生—临床医学]