单胺氧化酶A基因串联重复序列与童年期虐待对女性青少年冲动特质的影响  

The impact of childhood maltreatment experience and MAOA-VNTR on female adolescent's impulsivity trait

作　　者：张芸[1,2] 明庆森[2] 马丽荣[1] 李欣茹[1] 王艳芬[1] 

机构地区：[1]西北民族大学医学院,兰州730000 [2]中南大学湘雅二医院医学心理研究所

出　　处：《中国神经精神疾病杂志》2015年第5期281-287,共7页Chinese Journal of Nervous and Mental Diseases

基　　金：中央高校资助项目(编号:31920130038);兰州市科技局资助项目(编号:2014-1-101);西北民族大学科研创新团队(编号:xbmucxtd-2011-1)

摘　　要：目的探讨单胺氧化酶A串联重复序列(monoamine oxidase A variable nucleotide tandem repeat,MAOA-VNTR)基因型与童年期虐待经历各自及其交互作用对女性青少年冲动特质的影响。方法选取西北某地403名正常汉族女性青少年,完成Barratt冲动量表(Barratt impulsiveness scale,BIS)及童年创伤经历问卷(childhood trauma questionnaire,CTQ),采集其外周静脉血并进行DNA提取及MAOA-VNTR基因分型。采用线性回归分析MAOA-VNTR基因型、童年期虐待经历,以及其交互作用对冲动量表得分的影响。结果童年期虐待经历对女性青少年冲动特质的主效应具有统计学意义(P<0.01),而MAOA-VNTR基因型的主效应,以及MAOA-VNTR与童年虐待经历的交互作用均无统计学意义(均P>0.05)。结论本研究并未发现MAOA-VNTR基因型对童年期虐待所致女性青少年冲动具有调节作用。Objective To examine the impact on impulsivity trait by monoamine oxidase A variable nucleotide tan-dem repeat （MAOA-VNTR） genotype and children’s abuse experience. Methods The self-reported questionnaire of Bar-ratt Impulsiveness Scale （BIS）, Childhood Trauma Questionnaire （CTQ） were conducted in 403 normal Han female adoles-cents from north-west of China. The DNA were extracted from their venous blood sample and were genotyped for the MAOA-VNTR polymorphism. A linear regression model was used to investigate the main effects of MAOA-VNTR and children＇s abuse, and their interaction effect on impulsivity. Results The main effect of Children’s maltreatment experi-ence on trait impulsivity was significant （P0.05）. Conclusion The MAOA-VNTR genotype may not be involved in the female adolescents’impulsivity traits related to childhood maltreat-ment.

关 键 词：儿童期虐待 基因-环境交互作用 冲动 单胺氧化酶A基因串联重复序列 

分 类 号：B844[哲学宗教—发展与教育心理学]