GDNF及其受体GFRα1在小儿肾母细胞瘤中的表达及意义  

The expression of GDNF and GFRα1 in childhood nephroblastoma and its clinical significance

作　　者：张雪[1,2] 田娟[1] 赵越超[1,2] 郭芳[1] 

机构地区：[1]辽宁医学院组织学与胚胎学教研室,121001 [2]抚顺市中心医院

出　　处：《天津医药》2015年第6期628-630,I0001,共4页Tianjin Medical Journal

基　　金：辽宁省教育厅科学研究一般项目(L2012307);辽宁省科学技术计划项目(2013022067);辽宁省大学生创新创业训练计划项目(201410160037);国家大学生创新创业训练计划项目(201410160037)

摘　　要：目的研究胶质细胞源性神经营养因子(GDNF)及GDNF受体α1(GFRα1)在小儿肾母细胞瘤中的表达及其临床意义。方法应用免疫组织化学法检测GDNF及其受体GFRα1在30例小儿肾母细胞瘤组织及16例瘤旁正常肾组织病理石蜡标本中的表达。结果 GDNF在肾母细胞瘤中的阳性表达率高于瘤旁正常肾组织(66.7%vs6.3%),GFRα1在肾母细胞瘤中的阳性表达率高于瘤旁正常肾组织(63.3%vs 6.3%);两者在上皮型和胚芽成分强烈表达,在间叶成分表达较弱。GDNF及其受体GFRα1在不同组织分型、临床分期及有无淋巴结转移的患者间表达差异无统计学意义。结论肾母细胞瘤中GDNF及其受体GFRα1的高表达可能与肿瘤的发生密切相关。Objective To investigate the expressions of GDNF and GFRα1 in childhood nephroblastoma, and therefore its clinical significance. Methods The expression levels of GDNF and GFRα1 were examined by immunohistochemistry of 30 parrafin samples from nephroblastoma section as well as 16 parrafin samples of peritumor renal tissue. Results The pos-itive expression rate of GDNF and GFRα1 in nephroblastoma were higher than those in normal renal tissue（66.7%vs 6.3%;63.3%vs 6.3%）. GDNF and GFRα1 were strongly expressed in epithelium and embryo bud, but weakly expressed in lobus intermedius of nephroblastoma. There was no correlation between the expressions of GDNF and GFRα1 with histological types, clinical stage and metastasis of nephroblastoma of patients. Conclusion High expression of GDNF and GFRα1 in childhood nephroblastoma might indicate its role in tumor development.

关 键 词：肾母细胞瘤 胶质细胞源性神经营养因子 GDNF受体α1 免疫组织化学 

分 类 号：R737.1[医药卫生—肿瘤]