不同浓度氟化物对氟牙症釉质的影响  

Effects of fluoride on enamel hardness and microstructure of the teeth with dental fluorosis

作　　者：于永娜 张岱尊[1,2] 肖文林[1,2] 康鹏[1,2] 

机构地区：[1]青岛大学附属医院口腔医学中心 [2]青岛大学附属医院山东省教育厅口腔重点实验室,山东青岛266021 [3]潍坊市寒亭区人民医院口腔科,山东潍坊261000

出　　处：《牙体牙髓牙周病学杂志》2015年第6期375-377,共3页Chinese Journal of Conservative Dentistry

基　　金：山东省自然科学基金项目(ZR2010HM054)

摘　　要：目的:探讨不同浓度氟化物对氟牙症釉质硬度值及表面微观结构的影响。方法:收集临床拔除的中度氟斑恒牙56个,将每个牙冠部平均切割为3等份(n=56),分别列入A、B、C组。A组样本置于蒸馏水中,B组置于60 mg/L氟化钠液中,C组置于120 mg/L氟化钠液中。3组浸泡液均每天更换1次,并于37℃恒温箱放置10 d。用显微硬度计分别测定浸泡前后釉质表面硬度值,扫描电镜观察釉质表面微观及形态变化。结果:3组浸泡前釉质显微硬度均无显著差异(P>0.05);浸泡后,釉质显微硬度B组>A组>C组(P<0.05)。浸泡后釉质显微硬度与浸泡前相比:A组无明显变化(P>0.05),B组明显提高(P<0.05),C组明显降低(P<0.05)。除B组外,A、C组釉质表面未见反应物沉积。结论:高浓度氟化物可使氟斑牙硬度值降低,无釉质再矿化作用,氟牙症患者更适合用含有低浓度氟化物的牙膏。AIM：To study the effect of different concentrations of fluoride on dental enamel hardness and surface microstructure of the teeth with dental fluorosis. METHODS：56 extracted teeth with moderate fluorosis were collected and each crown was divided into 3 equal parts and set in group A, B and C respectively. The crown samples of group A, B and C were placed in distilled water, 60 mg/L and 120 mg/L sodium fluoride solution respectively in a 37℃ oven for 10 d. The solutions of the 3 groups were changed once daily. The hardness, microstructure and change of enamel surface of the samples were detected before and after immersion using micro hardness tester and scanning electron microscopy （SEM） respectively. RESULTS：No statistically significant difference was found in the enamel microhardness among the 3 groups before immer-sion （P 〉0. 05）. After soaking, the enamel microhardness of group B was higher than that of group A and group C （P0. 05）, in group B increased （P〈0. 05）, in group C reduced（P〈0. 05）. SEM observation showed that enamel surface in group B had reactive deposit, but in group A and group C had not. CONCLUSION：High concentration fluoride solution can decrease enamel hardness and remineralization of the teeth with dental fluorosis. Low con-centration fluoride toothpaste is more suitable for patients with dental fluorosis.

关 键 词：氟斑牙 牙釉质 氟化物 不同浓度 

分 类 号：R783.1[医药卫生—口腔医学]