维吾尔族与汉族大肠癌临床病理特征及hMLH1、hMSH2的表达差异  

Clinicopathological features and expression of h MLH1 and h MSH2 in Uygur and Han patients with colorectal carcinoma

作　　者：肉克彦.库达来提 岳娜[2] 梁莉萍[2] 赵峰[2] 

机构地区：[1]新疆医科大学基础医学院 [2]新疆医科大学附属肿瘤医院病理科

出　　处：《世界华人消化杂志》2015年第15期2382-2388,共7页World Chinese Journal of Digestology

摘　　要：目的:探讨新疆地区维吾尔族与汉族结直肠癌(colorectal cancer,CRC)临床病理特征及hMLH1和hMSH2蛋白表达差异.方法:回顾性分析284例CRC患者(维吾尔族133例,汉族151例)临床病理资料,采用免疫组织化学方法对207例(维吾尔族98例,汉族109例)CRC组织中hMLH1和hMSH2蛋白的表达进行检测.结果:(1)新疆地区维吾尔族CRC患者与汉族CRC患者在发病年龄、肿瘤大小、病理分型、淋巴结转移、TNM分期间的差异均具有统计学意义(P<0.05);(2)维吾尔族CRC患者中hMLH1蛋白表达缺失率为9.2%(9/98),hMSH2蛋白表达缺失率为3.1%(3/9 8);(3)hMLH1蛋白在肿瘤最大径>5.0 cm的CRC组织中的缺失率(17.1%)明显高于肿瘤最大径≤5.0 cm的CRC组织(3.5%,P<0.05),在有淋巴结转移的CRC组织中的缺失率(15.1%)明显高于无淋巴结转移的CRC组织(2.2%,P<0.05);(4)维吾尔族CRC患者中hMSH2蛋白缺失率(3.1%)明显低于汉族CRC患者(10.1%,P<0.05).结论:新疆地区维吾尔族CRC患者较汉族患者有发病年龄较轻,肿瘤直径较大,黏液腺癌及印戒细胞癌所占比例较高,TNM分期较晚等临床病理特点;且hMSH2蛋白在维吾尔族与汉族CRC患者中的表达具有种族差异性.AIM：To compare the differences in clinicopathological features and expression of hMLHl and hMSH2 between Uygur and Han patients with colorectal carcinoma.METHODS：The clinical data for 133 Uygur and 151 Han patients with colorectal carcinoma were analyzed retrospectively.The expression of hMLHl and hMSH2 proteins was detected in 207 colorectal carcinoma samples,including98 from Uygur and 109 from Han patients,by immunohistochemical staining.RESULTS：There were significant differences in onset age,tumor size,pathological differentiation,lymphatic metastasis and tumor stage between the Uygur group and Han group（P 〈 0.05）.In Uygur patients,the loss rate of hMLHl expression was 9.2%（9/98）in colorectal cancer tissue,and the loss rate of hMSH2 expression was 3.3%（3/98）.The loss rate of hMLHl expression in patients with tumor size 〉 5 cm was significantly higher than that in patients with tumor size ≤ 5 cm（17.1%vs 3.5%,P 〈 0.05）.The loss rate of hMLHl expression in patients with lymph node metastasis was 15.1%,significantly higher than that（2.2%） in patients without lymph node metastasis（P 〈 0.05）.The loss rate of hMSH2 in colorectal cancer tissue of Uygur patients（3.1%） was significantly lower than that（10.1%）in Han patients（P 〈 0.05）.CONCLUSION：There are differences in clinicopathologic features and expression of hMSH2 between Uygur and Han patients with colorectal carcinoma in Xinjiang.

关 键 词：结直肠癌 HMLH1基因 HMSH2基因 维吾尔族 汉族 

分 类 号：R735.34[医药卫生—肿瘤]