Kinetic study on reactive extraction of phenylalanine enantiomers with BINAP-copper complexes  

BINAP-铜配合物反应萃取苯丙氨酸对映体动力学研究(英文)

作　　者：唐课文 罗菁菁 张盼良 易健民 华杰 杨长安 

机构地区：[1]Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology [2]College of Chemistry, Xiangtan University

出　　处：《Chinese Journal of Chemical Engineering》2015年第1期57-63,共7页中国化学工程学报（英文版）

基　　金：Supported by the National Natural Science Foundation of China(21171054);the Open Fund Project of Key Laboratory in Hunan University(11K029);the Key Laboratory of Hunan Province and Aid program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province

摘　　要：Enantioselective liquid–liquid extraction has attracted considerable attention for its potential use in largescale production. Kinetic data are needed for the reliable scale-up of the process. This paper reports the kinetic study of reactive extraction of phenylalanine(Phe) enantiomers with BINAP–copper complex(BINAP–Cu) as a chiral selector. The theory of extraction accompanied by a chemical reaction was applied.The effects of agitation speed, interfacial area, p H value of aqueous phase, initial concentration of Phe enantiomers and initial concentration of BINAP–Cu on the specific rate of extraction were investigated. The forward rate constants of the reactions in the reactive extraction process are 7.93 × 10-5m5/2·mol-1/2·s-1for D-Phe and 1.29 × 10-4m5/2·mol-1/2·s-1for L-Phe.Enantioselective liquid–liquid extraction has attracted considerable attention for its potential use in largescale production. Kinetic data are needed for the reliable scale-up of the process. This paper reports the kinetic study of reactive extraction of phenylalanine（Phe） enantiomers with BINAP–copper complex（BINAP–Cu） as a chiral selector. The theory of extraction accompanied by a chemical reaction was applied.The effects of agitation speed, interfacial area, p H value of aqueous phase, initial concentration of Phe enantiomers and initial concentration of BINAP–Cu on the specific rate of extraction were investigated. The forward rate constants of the reactions in the reactive extraction process are 7.93 × 10-5m5/2·mol-1/2·s-1for D-Phe and 1.29 × 10-4m5/2·mol-1/2·s-1for L-Phe.

关 键 词：KINETICS Amino acids Modeling Liquid–liquid extraction ENANTIOMERS 

分 类 号：TQ246.37[化学工程—有机化工] TQ028.32