结直肠癌肝转移肝切除术后早期复发的危险因素  

Risk factors for early recurrence after curative hepatectomy for colorectal cancer liver metastases

作　　者：李华驰 刘佩[2] 王国洲[3] 王诗培[3] 陈双倩[3] 苏飞[3] 马翔[3] 谢伟[3] 冯茂辉[3] 

机构地区：[1]湖北省肿瘤医院胃肠外科,430079 [2]武汉大学中南医院感染科,430071 [3]肿瘤生物学行为湖北省重点实验室武汉大学中南医院肿瘤外科430071

出　　处：《中华实验外科杂志》2015年第7期1707-1709,共3页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金资助项目（81072152）;湖北省自然科学基金资助项目（2009CD201）;湖北省卫生厅科研资助项目（2013.JX6B20）;

摘　　要：目的 探讨结直肠癌肝转移（CRLM）肝切除术后早期复发的危险因素.方法 通过收集2004年1月至2013年12月武汉大学中南医院肿瘤科行根治性肝切除术的CRLM患者的病例资料,分析临床、病理等因素对CRLM患者肝切除术后早期复发的影响.结果 共纳入78例行根治性肝切除术的CRLM患者,其中30例出现早期复发,肝转移灶数量≥3个的CRLM患者术后早期复发的发生率明显高于数目＜3个的患者（60.0％比28.3％,P＜0.05）,肝转移数目≥3个与术后早期复发明显相关.结论 肝转移灶数目≥3个是肝切除术后早期复发的唯一独立危险因素,肝转移灶数目≥3个的患者早期复发的风险明显升高.Objective To investigate the risk factors for early recurrence after curative hepatectomy for colorectal cancer liver metastases （CRLM）.Methods A retrospective analysis was performed on patients who underwent curative hepatectomy for CRLM between 2004 and 2013 in order to find out the clinical and pathological factors influencing early recurrence.Results A total of 78 patients were included,including 30 patients with early recurrence.Patients with three or more liver metastases had significantly earlier recurrence than those with less than three liver metastases （60.0％ vs.28.3％,P ＜0.05）.Early recurrence was significantly associated with three or more liver metastases.Conclusion The independent risk factor for early recurrence was the ＂number of liver metastases ≥ 3 ＂.Patients with three or more liver metastases had significantly higher risk of early recurrence.

关 键 词：结直肠癌肝转移 肝切除术 早期复发 危险因素 

分 类 号：R735.35[医药卫生—肿瘤]