钙卫蛋白在炎性疾病中的表达及临床意义  

The expressions of calprotectin in inflammatory diseases and its clinical significance

作　　者：王旭[1] 黄立锋[2] 

机构地区：[1]首都医科大学第一临床医学院2011级五年制临床班,北京100020 [2]首都医科大学附属北京朝阳医院外科ICU

出　　处：《国际免疫学杂志》2015年第4期348-351,共4页International Journal of Immunology

基　　金：国家自然科学基金（81372042、30901561）;北京市卫生系统高层次卫生技术人才-学科骨于基金（2014-2-022）;北京市“科技新星汁划”资助项目（Z141107001814043）

摘　　要：炎性疾病作为临床常见病种，关于其诊断和治疗已成为医学研究中的一项重要任务。钙卫蛋白是一种由中性粒细胞所分泌，与炎症反应紧密相关的钙锌结合蛋白。随着近年来医学的发展，钙卫蛋白作为一种新的检测手段越来越受到重视。国内外已有较多有关钙卫蛋白与炎症性肠病、肝病、自身免疫病等炎性疾病关系的报道。研究表明，钙卫蛋白与上述疾病的严重程度明显相关，并可用来预测此类疾病的预后及复发情况。Inflammatory disease is common and its diagnosis is important. Calprotectin, a calcium-zinc binding protein secreted by neutrophils, is closely related to the inflammatory response. With the development of medicine,detecting calprotectin,as a newly developing test method, has been more and more valued in recent years. There have been many studies about the applications of calprotaction in inflammatory bowel disease （IBD）,hepatopathy,autoimmune disease and other inflammatory diseases. These studies have shown that cal- protectin is associated with the severity of these diseases,and it can be used to predict the prognosis and relapse of these diseases.

关 键 词：钙卫蛋白 炎性疾病 生物标志物 

分 类 号：R364[医药卫生—病理学]