MicroRNAs在呼吸系统疾病预防和治疗中的研究进展  

Advanced study on microRNAs involved in prevention and treatment of respiratory system diseases

作　　者：刘晓丽[1] 王如峰[1] 胡秀华[1] 

机构地区：[1]北京中医药大学基础医学院生物教研室,北京100029

出　　处：《中国药理学通报》2015年第7期895-899,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81274044)

摘　　要：近年来,由于空气质量下降,环境中的有害因子增加,呼吸系统疾病的发病率逐年升高,其预防和治疗成为目前关注的重点。研究表明MicroRNA参与多种呼吸系统疾病的预防和治疗,包括病毒感染性呼吸道疾病、肺纤维化、哮喘、慢性阻塞性肺病、肺结核以及肺部肿瘤。MicroRNA的上调和下调可有效地调节这些疾病的生物学过程,提示MicroRNA在呼吸系统疾病预防和治疗过程中起着重要的作用。综合分析近年来关于呼吸系统疾病与MicroRNA的研究报道,探讨MicroRNA在治疗和预防呼吸系统疾病中的作用,为呼吸道疾病的治疗和预防提供新的药物靶点。Recently, along with the harmful factors in air in-creasing, the incidence of respiratory system diseases has been gradually rising. Therefore, more studies are focused on impro-ving the prevention and treatment on respiratory system diseases. Current researches have shown that microRNAs ( miRNA ) con-tribute to the prevention and treatment on respiratory system dis-eases, including virus infectious respiratory disease, pulmonary fibrosis, asthma, COPD, pulmonary tuberculosis and lung canc-er. The up-regulation and down-regulation of microRNAs could effectively regulate the biological process of these diseases. The review analyzes the recent years′study results of respiratory sys-tem diseases and microRNAs in depth, and discuss the role of microRNA in the treatment and prevention of respiratory disea-ses. Moreover, in this review we can provide new knowledge a-bout respiratory diseases and development of more potent drug targets for the treatment and prevention of respiratory diseases.

关 键 词：微小RNA 病毒感染性呼吸道疾病 肺纤维化 哮喘 慢性阻塞性肺病 肺结核 肺癌 

分 类 号：R-05[医药卫生] R342.2