肺动脉压的检测方法优化研究  

Optimization of detection method of pulmonary arterial pressure

作　　者：卢志强[1] 张艳军[1] 庄朋伟[1] 张金保[1] 徐利满 孙凤娇[1] 

机构地区：[1]天津中医药大学天津市中药药理重点实验室,天津300193

出　　处：《中国药理学通报》2015年第7期1028-1032,共5页Chinese Pharmacological Bulletin

基　　金：国家重点基础研究发展规划(973计划)(No2011CB505300;2011CB505302)

摘　　要：目的优化传统大鼠右心导管术,建立一种快速、稳定、可靠的右心导管导引插管检测肺动脉压方法。方法选用90只♂wistar大鼠,对传统右心导管插管法进行优化研究,比较PE50、PUⅠ、PUⅡ3种导管插管成功率以及平均时间,改良传统大鼠右心导管术,并将改良后的右心导管导引插管法应用于肺动脉高压实验研究。结果 PUⅠ导管明显优于PE50及PUⅡ导管(P<0.05);右心导管导引插管法在插管成功率及插管时间上优于传统右心直接插管法(P<0.05或者P<0.01);运用改良后右心导管导引插管法检测的肺动脉高压大鼠血流动力学相关指标,压力波形规则,实验数据可靠。结论经改良后的右心导管导引插管法检测肺动脉压具有成功率高、操作简便快速等优点,在该领域研究中具有推广应用价值。Aim To optimize the traditional method of right catheterization in rats and establish a rapid , stable and reliable&nbsp;method of the right heart catheter guided intubation to measure pulmonary artery pressure. Methods Nighty male wistar rats were used to optimize the method of detection of pulmonary arte-rial pressure. Three catheter namely PE50, PU I, and PU II were used for choosing the best intubation. The new technology of right catheterization was established and used for the research of pulmonary arterial hypertension. Results The PU I catheter was obviously better than PE50 and PU II catheter in the success rate and measurement time ( P <0. 05 ) . The method of right heart catheter guided intubation was significantly superior to the traditional right heart direct intubation (P<0. 05 or P<0. 01). After improving the right catheterization, the detection of hemo-dynamic indexes in PAH-model rat was successful with regular pressure curve and reliable experimental data. Conclusions The right heart catheter guided intubation method has a high suc-cess rate and it can detect the pulmonary artery pressure quick-ly, easily, and can help other researchers to complete experi-ment as efficiently as possible.

关 键 词：肺动脉 压右心导管术 右心导管导引插管法 右心导管直接插管法 肺动脉高压 血流动力学 

分 类 号：R-332[医药卫生] R322.21